Analytical Data
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Gene name
FOSB
- Application
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Alternative Names
FosB proto-oncogene. AP-1 transcription factor subunit;G0/G1 switch regulatory protein 3;Transcription factor AP-1 subunit FosB
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P53539
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Expression Region
1-338aa
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AA Sequence
MFQAFPGDYDSGSRCSSSPSAESQYLSSVDSFGSPPTAAASQECAGLGEMPGSFVPTVTAITTSQDLQWLVQPTLISSMAQSQGQPLASQPPVVDPYDMPGTSYSTPGMSGYSSGGASGSGGPSTSGTTSGPGPARPARARPRRPREETLTPEEEEKRRVRRERNKLAAAKCRNRRRELTDRLQAETDQLEEEKAELESEIAELQKEKERLEFVLVAHKPGCKIPYEEGPGPGPLAEVRDLPGSAPAKEDGFSWLLPPPPPPPLPFQTSQDAPPNLTASLFTHSEVQVLGDPFPVVNPSYTSSFVLTCPEVSAFAGAQRTSGSDQPSDPLNSPSLLAL
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Molecular Weight
40.0 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
FOSB is a member of the Fos family of transcription factors, which play critical roles in cellular processes such as proliferation, differentiation, and apoptosis. Initially discovered as immediate early genes in response to growth factors and various stimuli, FOSB is known for its involvement in oncogenesis and its regulation of genes associated with neural activity and plasticity. The protein functions by forming heterodimers with Jun proteins, leading to the activation of target genes via specific promoter sequences. Research has shown that altered expression and activity of FOSB is linked to several pathological conditions, including cancer and neurodegenerative diseases. As such, the study of FOSB and its recombinant protein forms has gained significant attention, particularly in understanding its molecular mechanisms and potential roles as therapeutic targets. Researchers aim to elucidate the functional implications of FOSB in different biological contexts, exploring its potential as a biomarker for disease progression and as a candidate for novel treatment approaches. Through recombinant protein technology, scientists are investigating the structure, interactions, and regulatory mechanisms of FOSB, paving the way for innovations in medical science and biotechnology.
