Analytical Data
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Gene name
VIPR2
- Application
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Alternative Names
VIPR2; VIP2R; Vasoactive intestinal polypeptide receptor 2; VIP-R-2; Helodermin-preferring VIP receptor; Pituitary adenylate cyclase-activating polypeptide type III receptor; PACAP type III receptor; PACAP-R-3; PACAP-R3; VPAC2
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P41587
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Expression Region
1-438aa
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AA Sequence
MRTLLPPALLTCWLLAPVNSIHPECRFHLEIQEEETKCAELLRSQTEKHKACSGVWDNITCWRPANVGETVTVPCPKVFSNFYSKAGNISKNCTSDGWSETFPDFVDACGYSDPEDESKITFYILVKAIYTLGYSVSLMSLATGSIILCLFRKLHCTRNYIHLNLFLSFILRAISVLVKDDVLYSSSGTLHCPDQPSSWVGCKLSLVFLQYCIMANFFWLLVEGLYLHTLLVAMLPPRRCFLAYLLIGWGLPTVCIGAWTAARLYLEDTGCWDTNDHSVPWWVIRIPILISIIVNFVLFISIIRILLQKLTSPDVGGNDQSQYKRLAKSTLLLIPLFGVHYMVFAVFPISISSKYQILFELCLGSFQGLVVAVLYCFLNSEVQCELKRKWRSRCPTPSASRDYRVCGSSFSRNGSEGALQFHRGSRAQSFLQTETSVI
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Molecular Weight
73.92 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
VIPR2 (vasoactive intestinal peptide receptor 2) is a G protein-coupled receptor that plays a significant role in various physiological processes, including the regulation of circadian rhythms, neuroprotection, and immune responses. Its primary ligand, vasoactive intestinal peptide (VIP), is involved in neurotransmission and has been implicated in the modulation of inflammatory responses. Research into VIPR2 has gained momentum due to its potential therapeutic implications in treating disorders such as asthma, chronic obstructive pulmonary disease, and other inflammatory conditions. Moreover, understanding the structure and function of VIPR2 through recombinant protein studies allows for a better understanding of its signaling pathways and interaction with ligands. This insight is crucial for the development of selective agonists or antagonists as potential drug candidates. Additionally, studying VIPR2 can uncover its role in neurodegenerative diseases and circadian rhythm disorders, as it is expressed in various tissues, including the brain and peripheral organs. The production of recombinant VIPR2 proteins facilitates high-throughput screening of compounds, ultimately contributing to drug discovery efforts aimed at modulating this receptor's activity for therapeutic benefit. As such, research on VIPR2 recombinant proteins is vital for elucidating its biological functions and exploring its potential in clinical applications.
