Analytical Data
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基因名
MTF2
- Application
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别名
MTF2；PCL2；Metal-response element-binding transcription factor 2
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O43189
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表达区间
1-567aa
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氨基酸序列
MAQPPRLSRS GASSLWDPAS PAPTSGPRPR LWEGQDVLAR WTDGLLYLGT IKKVDSAREV CLVQFEDDSQ FLVLWKDISP AALPGEELLC CVCRSETVVP GNRLVSCEKC RHAYHQDCHV PRAPAPGEGE GTSWVCRQCV FAIATKRGGA LKKGPYARAM LGMKLSLPYG LKGLDWDAGH LSNRQQSYCY CGGPGEWNLK MLQCRSCLQW FHEACTQCLS KPLLYGDRFY EFECCVCRGG PEKVRRLQLR WVDVAHLVLY HLSVCCKKKY FDFDREILPF TSENWDSLLL GELSDTPKGE RSSRLLSALN SHKDRFISGR EIKKRKCLFG LHARMPPPVE PPTGDGALTS FPSGQGPGGG VSRPLGKRRR PEPEPLRRRQ KGKVEELGPP SAVRNQPEPQ EQRERAHLQR ALQASVSPPS PSPNQSYQGS SGYNFRPTDA RCLPSSPIRM FASFHPSAST AGTSGDSGPP DRSPLELHIG FPTDIPKSAP HSMTASSSSV SSPSPGLPRR SAPPSPLCRS LSPGTGGGVR GGVGYLSRGD PVRVLARRVR PDGSVQYLVE WGGGGIF
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分子量
62.1 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MTF2 (Metal Regulatory Transcription Factor 2) is a pivotal protein that plays a significant role in cellular metal ion regulation and oxidative stress response. Research surrounding MTF2 has gained momentum due to its involvement in various biological processes, including the modulation of gene expression linked to metal homeostasis, cell survival, and apoptosis. Mutations or dysregulation of MTF2 have been associated with several pathological conditions, including neurodegenerative diseases and certain cancers. As a transcription factor, MTF2 binds to metal response elements in the promoter regions of target genes, facilitating the expression of genes that help mitigate metal toxicity and oxidative damage. Recent studies have focused on elucidating the structural characteristics and functional mechanisms of MTF2, revealing its potential as a therapeutic target for diseases related to metal ion imbalance. Moreover, its role in epigenetic regulation has opened new avenues for understanding cellular adaptation to environmental stresses. Overall, research on MTF2 not only provides insights into fundamental biological mechanisms but also holds promise for developing novel strategies to combat diseases linked to metal dysregulation and oxidative stress.
