Analytical Data
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Gene name
FMO5
- Application
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Alternative Names
FMO 5;Baeyer-Villiger monooxygenase 1;hBVMO1;Dimethylaniline oxidase 5;NADPH oxidase
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P49326
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Expression Region
1-533aa
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AA Sequence
MTKKRIAVIGGGVSGLSSIKCCVEEGLEPVCFERTDDIGGLWRFQENPEEGRASIYKSVIINTSKEMMCFSDYPIPDHYPNFMHNAQVLEYFRMYAKEFDLLKYIRFKTTVCSVKKQPDFATSGQWEVVTESEGKKEMNVFDGVMVCTGHHTNAHLPLESFPGIEKFKGQYFHSRDYKNPEGFTGKRVIIIGIGNSGGDLAVEISQTAKQVFLSTRRGAWILNRVGDYGYPADVLFSSRLTHFIWKICGQSLANKYLEKKINQRFDHEMFGLKPKHRALSQHPTLNDDLPNRIISGLVKVKGNVKEFTETAAIFEDGSREDDIDAVIFATGYSFDFPFLEDSVKVVKNKISLYKKVFPPNLERPTLAIIGLIQPLGAIMPISELQGRWATQVFKGLKTLPSQSEMMAEISKAQEEIDKRYVESQRHTIQGDYIDTMEELADLVGVRPNLLSLAFTDPKLALHLLLGPCTPIHYRVQGPGKWDGARKAILTTDDRIRKPLMTRVVERSSSMTSTMTIGKFMLALAFFAIIIAYF
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Molecular Weight
73.2 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
FMO5 (Flavin-containing Monooxygenase 5) is a member of the flavin-containing monooxygenase enzyme family, known for its role in the oxidation of a wide variety of xenobiotics and endogenous compounds. Research into FMO5 is significant due to its involvement in metabolizing drugs and other substances, impacting pharmacogenomics and toxicology. Unlike other FMO family members, which have well-established pathways in drug metabolism, the specific functions and substrates of FMO5 remain less characterized, presenting a gap in our understanding of its biological role. Recent studies have suggested that FMO5 may contribute to the metabolism of certain psychoactive substances, as well as influence the bioactivation of toxins. Additionally, its expression levels and activity can vary among individuals, underscoring the importance of FMO5 in personalized medicine. The recombinant FMO5 protein has been utilized in laboratory studies to analyze its enzymatic properties, substrate specificity, and interactions with various pharmaceuticals. Overall, understanding FMO5's biochemical properties and clinical implications can enhance our knowledge of drug metabolism and aid in the development of safer and more effective therapeutic agents. This area of research is crucial for advancing precision medicine, improving drug safety profiles, and minimizing adverse drug reactions associated with variances in individual metabolic pathways.
