Analytical Data
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Gene name
TMOD1
- Application
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Alternative Names
TMOD1；D9S57E；TMOD；Tropomodulin-1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P28289
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Expression Region
1-359aa
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AA Sequence
MSYRRELEKYRDLDEDEILGALTEEELRTLENELDELDPDNALLPAGLRQKDQTTKAPTGPFKREELLDHLEKQAKEFKDREDLVPYTGEKRGKVWVPKQKPLDPVLESVTLEPELEEALANASDAELCDIAAILGMHTLMSNQQYYQALSSSSIMNKEGLNSVIKPTQYKPVPDEEPNSTDVEETLERIKNNDPKLEEVNLNNIRNIPIPTLKAYAEALKENSYVKKFSIVGTRSNDPVAYALAEMLKENKVLKTLNVESNFISGAGILRLVEALPYNTSLVEMKIDNQSQPLGNKVEMEIVSMLEKNATLLKFGYHFTQQGPRLRASNAMMNNNDLVRKRRLADLTGPIIPKCRSGV
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Molecular Weight
67.6 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TMOD1 (Tropomodulin 1) is a key regulatory protein associated with the maintenance of actin filament integrity in muscle and non-muscle cells. It binds to the pointed end of actin filaments, preventing depolymerization and thereby playing a critical role in the stabilization of the cytoskeleton, which is essential for various cellular functions including motility, shape, and intracellular transport. TMOD1 is particularly important in striated muscles, where it contributes to the structural organization of myofibrils. Recent studies have shown that alterations in TMOD1 expression or function can lead to various muscular disorders, including cardiomyopathies and skeletal muscle pathologies. Understanding the molecular mechanisms governing TMOD1's role in actin dynamics is crucial for deciphering the pathophysiological processes underlying these diseases. As a recombinant protein, TMOD1 can be produced in vitro, allowing researchers to investigate its biochemical properties, interactions with other cytoskeletal proteins, and effects on actin polymerization and depolymerization processes. Furthermore, the study of TMOD1 in recombinant form provides a valuable tool for potential therapeutic applications, where targeting its regulatory functions may offer new avenues for alleviating actin-related disorders. Overall, the investigation of TMOD1 as a recombinant protein has significant implications for the fields of cell biology, muscle physiology, and translational medicine.
