Analytical Data
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基因名
FMO4
- Application
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别名
FMO4; FMO2; Dimethylaniline monooxygenase [N-oxide-forming] 4; Dimethylaniline oxidase 4; Hepatic flavin-containing monooxygenase 4; FMO 4
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P31512
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表达区间
206-301aa
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氨基酸序列
TAAQVLLSTRTGTWVLGRSSDWGYPYNMMVTRRCCSFIAQVLPSRFLNWIQERKLNKRFNHEDYGLSITKGKKAKFIVNDELPNCILCGAITMKTS
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分子量
36.3 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
FMO4 (Flavin-containing monooxygenase 4) is an enzyme belonging to the flavin-containing monooxygenases family, which plays a crucial role in the metabolism of various xenobiotics and endogenous compounds. Research on FMO4 has gained significance due to its involvement in drug metabolism, as it converts nucleophilic compounds into less toxic metabolites through oxidative reactions. Variations in the expression and activity of FMO4 have been linked to individual differences in drug efficacy and toxicity, making it a focal point in pharmacogenomics. Additionally, FMO4 is implicated in the metabolism of dietary substances and neurotransmitters, further underscoring its importance in human health and disease. Understanding the structure and function of FMO4, particularly through recombinant protein studies, allows researchers to explore its catalytic mechanisms and interactions with drug substrates. This research holds promise for optimizing therapeutic strategies and mitigating adverse drug reactions by elucidating individual metabolic profiles influenced by FMO4 activity. As the understanding of FMO4 continues to expand, it may also provide insights into its potential role in various disease states and contribute to the development of personalized medicine approaches.
