Analytical Data
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Gene name
PRM1
- Application
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Alternative Names
PRM1；Sperm protamine P1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P04553
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Expression Region
2-51aa
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AA Sequence
ARYRCCRSQ SRSRYYRQRQ RSRRRRRRSC QTRRRAMRCC RPRYRPRCRR H
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PRM1, or Protamine 1, is a protein predominantly found in the sperm of various vertebrates, playing a crucial role in sperm maturation and chromatin condensation during spermiogenesis. This highly basic protein is essential for packaging DNA tightly within the sperm nucleus, thereby ensuring genetic integrity and successful fertilization. In recent years, research into PRM1 has expanded to explore its potential implications in fertility treatments and reproductive health, especially considering that abnormalities in protamine protamine composition or function can lead to compromised sperm function and infertility. The investigation of PRM1 also extends to its potential roles in genetic diseases and male reproductive disorders, highlighting the importance of understanding its structure, function, and regulatory mechanisms. Advances in recombinant DNA technology have facilitated the production of recombinant PRM1 protein, allowing for in-depth studies of its biochemical properties and interactions with other molecules. Overall, ongoing research on PRM1 reaffirms its significance not only in reproductive biology but also in broader biomedical contexts, where insights into its functionality may yield novel therapeutic strategies for managing male infertility and enhancing reproductive technologies.
