Analytical Data
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Gene name
MC5R
- Application
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Alternative Names
MC5R；Melanocortin receptor 5
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P33032
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Expression Region
1-325aa
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AA Sequence
MNSSFHLHFLDLNLNATEGNLSGPNVKNKSSPCEDMGIAVEVFLTLGVISLLENILVIGAIVKNKNLHSPMYFFVCSLAVADMLVSMSSAWETITIYLLNNKHLVIADAFVRHIDNVFDSMICISVVASMCSLLAIAVDRYVTIFYALRYHHIMTARRSGAIIAGIWAFCTGCGIVFILYSESTYVILCLISMFFAMLFLLVSLYIHMFLLARTHVKRIAALPGASSARQRTSMQGAVTVTMLLGVFTVCWAPFFLHLTLMLSCPQNLYCSRFMSHFNMYLILIMCNSVMDPLIYAFRSQEMRKTFKEIICCRGFRIACSFPRRD
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Molecular Weight
38.0 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The Melanocortin 5 receptor (MC5R) is a vital member of the melanocortin receptor family, which plays a significant role in various physiological processes, including lipid metabolism, energy homeostasis, and inflammatory responses. The MC5R is primarily expressed in adipose tissue, skin, and certain brain areas, making it an important target for studying metabolic disorders and obesity. Recent advances in biotechnology have enabled the production of recombinant MC5R proteins, allowing researchers to explore its structure, function, and interactions with various ligands in greater detail. Understanding the signaling pathways related to MC5R activation can shed light on its role in conditions such as obesity, diabetes, and skin disorders. Furthermore, investigating the receptor's potential as a therapeutic target can pave the way for the development of novel treatments aimed at regulating energy balance and metabolic health. The recombinant MC5R protein serves as a valuable tool for drug screening and the design of MC5R-based therapies, enhancing our ability to manipulate this receptor's activity for beneficial health outcomes. Overall, the study of MC5R and its recombinant protein forms is crucial in the broader context of metabolic research and pharmacological innovations.
