Analytical Data
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Gene name
UTF1
- Application
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Alternative Names
hUTF 1; hUTF1; Undifferentiated embryonic cell transcription factor 1; UTF 1; UTF1; UTF1_HUMAN
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q5T230
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Expression Region
1-341 aa
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AA Sequence
MLLRPRRPPP LAPPAPPSPA SPDPEPRTPG DAPGTPPRRP ASPSALGELG LPVSPGSAQR TPWSARETEL LLGTLLQPAV WRALLLDRRQ ALPTYRRVSA ALAQQQVRRT PAQCRRRYKF LKDKFREAHG QPPGPFDEQI RKLMGLLGDN GRKRPRRRSP GSGRPQRARR PVPNAHAPAP SEPDATPLPT ARDRDADPTW TLRFSPSPPK SADASPAPGS PPAPAPTALA TCIPEDRAPV RGPGSPPPPP AREDPDSPPG RPEDCAPPPA APPSLNTALL QTLGHLGDIA NILGPLRDQL LTLNQHVEQL RGAFDQTVSL AVGFILGSAA AERGVLRDPC Q
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Molecular Weight
36.4 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
UTF1 (Ubiquitously Transcribed Tetratricopeptide Repeat Protein 1) is a crucial protein primarily associated with pluripotency and early embryonic development. It plays a significant role in maintaining stem cell characteristics and regulating gene expression through interactions with various transcription factors and other proteins. Research on UTF1 has gained momentum due to its potential implications in regenerative medicine and cancer biology. Scientists have been investigating its mechanisms of action and the molecular pathways it influences, particularly in stem cells and differentiated cells. Studies have shown that UTF1 is involved in key cellular processes such as apoptosis, differentiation, and cellular reprogramming. Moreover, its unique structure, characterized by tetratricopeptide repeats (TPRs), enables it to participate in protein-protein interactions, suggesting that UTF1 may act as a scaffold or mediator in various biological processes. Understanding the role of UTF1 in these contexts could provide insights into developmental biology and yield therapeutic targets for diseases where cellular identity and pluripotency are disrupted. Given its widespread expression and functional importance, UTF1 continues to be a significant focus of research in molecular and cellular biology, as scientists aim to unravel the complexities of stem cell regulation and develop innovative strategies for tissue engineering and cancer treatment.
