Analytical Data
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基因名
HIST1H1A
- Application
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别名
HIST1H1A；H1F1；HIST1H1A；Histone H1.1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8IZA3
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表达区间
1-346aa
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氨基酸序列
MAPGSVTSDI SPSSTSTAGS SRSPESEKPG PSHGGVPPGG PSHSSLPVGR RHPPVLRMVL EALQAGEQRR GTSVAAIKLY ILHKYPTVDV LRFKYLLKQA LATGMRRGLL ARPLNSKARG ATGSFKLVPK HKKKIQPRKM APATAPRRAG EAKGKGPKKP SEAKEDPPNV GKVKKAAKRP AKVQKPPPKP GAATEKARKQ GGAAKDTRAQ SGEARKVPPK PDKAMRAPSS AGGLSRKAKA KGSRSSQGDA EAYRKTKAES KSSKPTASKV KNGAASPTKK KVVAKAKAPK AGQGPNTKAA APAKGSGSKV VPAHLSRKTE APKGPRKAGL PIKASSSKVS SQRAE
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
HIST1H1A, a member of the histone H1 family, plays a critical role in the packaging of DNA into chromatin, contributing to the regulation of gene expression and maintaining genomic integrity. The study of HIST1H1A recombinant proteins has gained significant attention due to their potential implications in understanding various biological processes and diseases, particularly cancer. Histone modifications, including those involving HIST1H1A, are integral to the epigenetic regulation of genes, influencing cellular differentiation, proliferation, and apoptosis. Abnormal expression or modification of HIST1H1A has been implicated in several malignancies, suggesting that it may serve as a biomarker for cancer prognosis or as a therapeutic target. Furthermore, recombinant HIST1H1A proteins can be utilized in biochemical assays to elucidate their interactions with other chromatin-associated proteins and to investigate their roles in chromatin remodeling. The ability to produce HIST1H1A in a recombinant form allows researchers to explore its structural features and functional mechanisms in vitro, bridging gaps in our understanding of epigenetic regulation. As studies move forward, these insights into HIST1H1A will significantly enhance our comprehension of cellular processes and might pave the way for novel therapeutic strategies in oncology and regenerative medicine.
