Analytical Data
-
Gene name
USP24
- Application
-
Alternative Names
Deubiquitinating enzyme 24; KIAA1057; Ubiquitin carboxyl terminal hydrolase 24; Ubiquitin carboxyl-terminal hydrolase 24; Ubiquitin specific peptidase 24; Ubiquitin specific processing protease 24; Ubiquitin specific protease 24; Ubiquitin thioesterase 24; Ubiquitin thiolesterase 24; Ubiquitin-specific-processing protease 24; UBP24_HUMAN; Usp24
-
Species
Human
-
Source
E. coli
-
Tag
GST-tag at N-terminal
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
Q9UPU5
-
Expression Region
1-309 aa
-
AA Sequence
MISFLLGASRQNNQIRRWSSAQAREFGNLHNTVALLVLHSDVSSQRNVAPGIFKQRPPISIAPSSPLLPLHEEVEALLFMSEGKPYLLEVMFALRELTGSLLALIEMVVYCCFCNEHFSFTMLHFIKNQLETAPPHELKNTFQLLHEILVIEDPIQVERVKFVFETENGLLALMHHSNHVDSSRCYQCVKFLVTLAQKCPAAKEYFKENSHHWSWAVQWLQKKMSEHYWTPQSNVSNETSTGKTFQRTISAQDTLAYATALLNEKEQSGSSNGSESSPANENGDRHLQQGSESPMMIGELRSDLDDVDP
-
Molecular Weight
59.73 kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
USP24 is a member of the Ubiquitin-Specific Proteases (USPs) family, which play crucial roles in the regulation of various cellular processes by removing ubiquitin moieties from target proteins, thus modulating their stability and activity. Research on USP24 has gained attention due to its involvement in key biological functions such as cell cycle regulation, DNA damage response, and apoptosis. Abnormal expression or activity of USP24 has been linked to several diseases, including cancer, where it may contribute to tumor progression by influencing the degradation of oncogenic and tumor suppressor proteins. The study of USP24's structure and function offers insight into its specific substrate interactions and regulatory mechanisms, making it a potential target for therapeutic interventions. Recent advances in proteomics and biochemistry have provided novel tools to explore the substrate specificity and regulatory pathways involving USP24. Understanding the role of USP24 in maintaining cellular homeostasis and its implications in pathological conditions will pave the way for developing targeted therapies aimed at modulating its activity for clinical benefits.
