Analytical Data
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基因名
HRH4
- Application
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别名
HRH4；GPCR105；Histamine H4 receptor
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9H3N8
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表达区间
1-390aa
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氨基酸序列
MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFVGVISIPLYIPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAVSYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDEGSECEPGFFSEWYILAITSFLEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSASTEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPLCHKRFQKAFLKIFCIKKQPLPSQHSRSVSS
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分子量
44.4 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
HRH4, or Histamine Receptor H4, is a G-protein-coupled receptor primarily expressed in immune cells, playing a crucial role in modulating inflammatory responses and immune system regulation. The study of HRH4 recombinant proteins has gained significant attention due to their potential implications in various pathological conditions, including asthma, allergies, and autoimmune diseases. Unlike other histamine receptors, HRH4 is predominantly involved in the chemotaxis of immune cells and the release of pro-inflammatory cytokines, suggesting its critical role in shaping immune responses. Research has indicated that targeting HRH4 may provide therapeutic avenues for treating inflammatory disorders, enhancing immune response in cancer therapies, and offering new strategies for controlling allergic reactions. By utilizing recombinant DNA technology, scientists can produce HRH4 proteins for structural and functional analysis, paving the way for drug discovery and the development of HRH4 antagonists or agonists. Understanding the signaling pathways associated with HRH4 activation will further elucidate its role in immune responses and provide insights into its pharmacological potential, making HRH4 a promising target in immunotherapy and personalized medicine.
