Analytical Data
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基因名
HRH1
- Application
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别名
HRH1;Histamine H1 receptor
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P35367
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表达区间
211-416aa
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氨基酸序列
AKIYKAVRQHCQHRELINRSLPSFSEIKLRPENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKLYCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSRTDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQ
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分子量
27.1 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
HRH1, or the histamine receptor H1, is a crucial member of the histamine receptor family and plays a significant role in various physiological processes, including allergic responses, neurotransmission, and regulation of immune function. Recent studies highlight the importance of HRH1 in mediating allergic reactions and inflammatory processes, making it a target for drug discovery, especially for antihistamines and other therapeutic agents. The recombinant expression of HRH1 protein has enabled researchers to investigate its structural and functional properties more effectively. By producing HRH1 in heterologous systems, such as bacteria or mammalian cells, scientists can obtain a sufficient quantity of biologically active protein for detailed studies. Understanding the 3D structure of HRH1 and its interaction with ligands can facilitate the design of more selective and effective drugs, potentially leading to better management of conditions like allergic rhinitis, asthma, and other histamine-related disorders. Moreover, recombinant HRH1 is fundamental in developing biochemical assays and screening platforms to identify novel compounds that target this receptor. Consequently, research into HRH1 recombinant protein not only contributes to the broader understanding of receptor biology but also presents promising avenues for therapeutic innovations in treating histamine-related diseases.












