Analytical Data
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基因名
USP20
- Application
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别名
Deubiquitinating enzyme 20; hVDU2; KIAA1003; LSFR 3A; LSFR3A; pVHL interacting deubiquitinating enzyme 2; Ubiquitin carboxyl terminal hydrolase 20; Ubiquitin carboxyl-terminal hydrolase 20; ubiquitin specific peptidase 20; Ubiquitin specific processing protease 20; Ubiquitin specific protease 20; Ubiquitin thioesterase 20; Ubiquitin thiolesterase 20; Ubiquitin-specific-processing protease 20; UBP20_HUMAN; USP 20; USP20; VDU 2; VDU2; VHL interacting deubiquitinating enzyme 2; VHL-interacting deubiquitinating enzyme 2
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9Y2K6
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表达区间
1-913 aa
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氨基酸序列
MGDSRDLCPHLDSIGEVTKEDLLLKSKGTCQSCGVTGPNLWACLQVACPYVGCGESFADHSTIHAQAKKHNLTVNLTTFRLWCYACEKEVFLEQRLAAPLLGSSSKFSEQDSPPPSHPLKAVPIAVADEGESESEDDDLKPRGLTGMKNLGNSCYMNAALQALSNCPPLTQFFLECGGLVRTDKKPALCKSYQKLVSEVWHKKRPSYVVPTSLSHGIKLVNPMFRGYAQQDTQEFLRCLMDQLHEELKEPVVATVALTEARDSDSSDTDEKREGDRSPSEDEFLSCDSSSDRGEGDGQGRGGGSSQAETELLIPDEAGRAISEKERMKDRKFSWGQQRTNSEQVDEDADVDTAMAALDQPAEAQPPSPRSSSPCRTPEPDNDAHLRSSSRPCSPVHHHEGHAKLSSSPPRASPVRMAPSYVLKKAQVLSAGSRRRKEQRYRSVISDIFDGSILSLVQCLTCDRVSTTVETFQDLSLPIPGKEDLAKLHSAIYQNVPAKPGACGDSYAAQGWLAFIVEYIRRFVVSCTPSWFWGPVVTLEDCLAAFFAADELKGDNMYSCERCKKLRNGVKYCKVLRLPEILCIHLKRFRHEVMYSFKINSHVSFPLEGLDLRPFLAKECTSQITTYDLLSVICHHGTAGSGHYIAYCQNVINGQWYEFDDQYVTEVHETVVQNAEGYVLFYRKSSEEAMRERQQVVSLAAMREPSLLRFYVSREWLNKFNTFAEPGPITNQTFLCSHGGIPPHKYHYIDDLVVILPQNVWEHLYNRFGGGPAVNHLYVCSICQVEIEALAKRRRIEIDTFIKLNKAFQAEESPGVIYCISMQWFREWEAFVKGKDNEPPGPIDNSRIAQVKGSGHVQLKQGADYGQISEETWTYLNSLYGGGPEIAIRQSVAQPLGPENLHGEQKIEAETRAV
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分子量
128.3 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
USP20, or Ubiquitin-specific peptidase 20, is a member of the USP family of deubiquitinating enzymes that play a crucial role in the regulation of protein stability and signaling pathways by removing ubiquitin moieties from target proteins. Research on USP20 has gained significant attention due to its involvement in various physiological processes and diseases, including cancer. By regulating the degradation of key proteins involved in cell cycle progression and apoptosis, USP20 has been implicated in tumorigenesis and cancer progression. Previous studies have suggested that aberrant expression or activity of USP20 can lead to the stabilization of oncogenic proteins or the degradation of tumor suppressors, thereby contributing to the malignant phenotype. Furthermore, USP20 has been investigated for its potential role in immune response regulation and neurodegenerative diseases. Understanding the structural and functional characteristics of USP20, as well as its molecular interactions, is essential for developing targeted therapeutic strategies that could modulate its activity. Recent advancements in recombinant protein technology have facilitated the production of USP20 for detailed biochemical studies, enabling researchers to explore its substrate specificity, enzymatic mechanisms, and potential as a drug target. As a result, the study of USP20 not only enhances our understanding of ubiquitin-mediated signaling but also holds promise for innovative therapeutic approaches in treating diseases linked to its dysregulation.
