Analytical Data
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Gene name
TNP2
- Application
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Alternative Names
TNP2；Transportin-2
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q05952
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Expression Region
1-138aa
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AA Sequence
MDTQTHSLPI THTQLHSNSQ PQSRTCTRHC QTFSQSCRQS HRGSRSQSSS QSPASHRNPT GAHSSSGHQS QSPNTSPPPK RHKKTMNSHH SPMRPTILHC RCPKNRKNLE GKLKKKKMAK RIQQVYKTKT RSSGWKSN
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TNP2, or Testis Nuclear Protein 2, is a protein that plays a crucial role in spermatogenesis and male fertility. It is primarily expressed in the testis, where it is involved in chromatin remodeling and gene regulation during the differentiation of spermatogenic cells. Recent studies have suggested that TNP2 may also contribute to fertility issues when its expression is disrupted. The investigation of TNP2 recombinant protein is significant for understanding its functional mechanisms and potential implications in male reproductive health. By producing TNP2 as a recombinant protein, researchers aim to elucidate its structural properties and interactions with DNA and other nuclear proteins. This research holds promise for identifying novel targets for therapeutic intervention in infertility and for enhancing our understanding of the molecular underpinnings of testicular function. Additionally, as TNP2 is a candidate biomarker for certain types of male infertility, its recombinant form could facilitate the development of diagnostic tools. Further exploration of TNP2's role at the biochemical level may yield insights into male reproductive disorders and lead to the advancement of reproductive technologies. Thus, the study of TNP2 recombinant protein not only enhances our knowledge of testicular biology but also has the potential to contribute to clinical applications in reproductive health.
