Analytical Data
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Gene name
UNC84B
- Application
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Alternative Names
SUN2; FRIGG; KIAA0668; RAB5IP; UNC84B; SUN domain-containing Protein 2; Protein unc-84 homolog B; Rab5-interacting Protein; Rab5IP; Sad1/unc-84 Protein-like 2
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9UH99
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Expression Region
1-717 aa
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AA Sequence
MSRRSQRLTRYSQGDDDGSSSSGGSSVAGSQSTLFKDSPLRTLKRKSSNMKRLSPAPQLGPSSDAHTSYYSESLVHESWFPPRSSLEELHGDANWGEDLRVRRRRGTGGSESSRASGLVGRKATEDFLGSSSGYSSEDDYVGYSDVDQQSSSSRLRSAVSRAGSLLWMVATSPGRLFRLLYWWAGTTWYRLTTAASLLDVFVLTRRFSSLKTFLWFLLPLLLLTCLTYGAWYFYPYGLQTFHPALVSWWAAKDSRRPDEGWEARDSSPHFQAEQRVMSRVHSLERRLEALAAEFSSNWQKEAMRLERLELRQGAPGQGGGGGLSHEDTLALLEGLVSRREAALKEDFRRETAARIQEELSALRAEHQQDSEDLFKKIVRASQESEARIQQLKSEWQSMTQESFQESSVKELRRLEDQLAGLQQELAALALKQSSVAEEVGLLPQQIQAVRDDVESQFPAWISQFLARGGGGRVGLLQREEMQAQLRELESKILTHVAEMQGKSAREAAASLSLTLQKEGVIGVTEEQVHHIVKQALQRYSEDRIGLADYALESGGASVISTRCSETYETKTALLSLFGIPLWYHSQSPRVILQPDVHPGNCWAFQGPQGFAVVRLSARIRPTAVTLEHVPKALSPNSTISSAPKDFAIFGFDEDLQQEGTLLGKFTYDQDGEPIQTFHFQAPTMATYQVVELRILTNWGHPEYTCIYRFRVHGEPAH
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Molecular Weight
105.27 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
UNC84B, a member of the UNC84 family of proteins, has garnered significant attention in recent years due to its involvement in various cellular processes, particularly in the realm of cellular transport and intracellular signaling. Originally identified in studies focusing on cellular morphology and migration in model organisms such as *Caenorhabditis elegans*, UNC84B has emerged as a crucial player in the functioning of the nuclear envelope and its interactions with the cytoskeleton. Research has indicated that UNC84B is integral to the proper localization of nuclear components and plays a role in maintaining nuclear structure, thereby influencing gene expression and cellular responses to environmental cues. Moreover, its association with diseases such as muscular dystrophy and certain cancers highlights its potential as a therapeutic target. The recombinant production of UNC84B facilitates detailed studies of its structural and functional properties, allowing researchers to dissect its mechanisms of action and interactions with other cellular proteins. Understanding the biophysical characteristics and biological roles of UNC84B can provide insights into fundamental cellular processes and contribute to the development of novel strategies for addressing related pathologies. Overall, UNC84B represents a significant focus of research in cell biology, with implications reaching far beyond its initial characterization, pointing towards its potential impact in therapeutic applications and disease prevention.
