Analytical Data
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Gene name
Ntn1
- Application
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Alternative Names
Ntn1；NTN1L；Netrin-1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O95631
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Expression Region
25-604aa
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AA Sequence
GPGLSM FAGQAAQPDP CSDENGHPRR CIPDFVNAAF GKDVRVSSTC GRPPARYCVV SERGEERLRS CHLCNASDPK KAHPPAFLTD LNNPHNLTCW QSENYLQFPH NVTLTLSLGK KFEVTYVSLQ FCSPRPESMA IYKSMDYGRT WVPFQFYSTQ CRKMYNRPHR APITKQNEQE AVCTDSHTDM RPLSGGLIAF STLDGRPSAH DFDNSPVLQD WVTATDIRVA FSRLHTFGDE NEDDSELARD SYFYAVSDLQ VGGRCKCNGH AARCVRDRDD SLVCDCRHNT AGPECDRCKP FHYDRPWQRA TAREANECVA CNCNLHARRC RFNMELYKLS GRKSGGVCLN CRHNTAGRHC HYCKEGYYRD MGKPITHRKA CKACDCHPVG AAGKTCNQTT GQCPCKDGVT GITCNRCAKG YQQSRSPIAP CIKIPVAPPT TAASSVEEPE DCDSYCKASK GKLKINMKKY CKKDYAVQIH ILKADKAGDW WKFTVNIISV YKQGTSRIRR GDQSLWIRSR DIACKCPKIK PLKKYLLLGN AEDSPDQSGI VADKSSLVIQ WRDTWARRLR KFQQREKKGK CKKA
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Ntn1, or Netrin-1, is a signaling protein that plays a crucial role in guiding neural development and establishing connections within the nervous system. First identified for its role in promoting axon outgrowth and neuronal migration, Ntn1 acts as a Netrin family ligand that interacts with various receptors, such as DCC (Deleted in Colorectal Cancer) and UNC5, to regulate cellular processes crucial for neural patterning. Research has revealed that Ntn1 is not only vital during embryonic development but also significant in adult neurogenesis, synaptic plasticity, and various neurodegenerative diseases. Its involvement in these processes has generated interest in studying Ntn1 as a potential therapeutic target for repairing neural injuries and treating conditions like spinal cord injuries, Alzheimer's disease, and schizophrenia. Recent advancements in recombinant protein technology have made it possible to produce large quantities of Ntn1 for in-depth functional studies, enabling researchers to investigate its molecular mechanisms, interactions, and effects on neuronal behaviors in vitro and in vivo models. Understanding Ntn1's diverse biological roles could provide insights into designing novel strategies for neuroregenerative therapies and improving outcomes for patients with nervous system disorders. Thus, the study of recombinant Ntn1 is positioned at the intersection of molecular biology, neuroscience, and therapeutic innovation, with significant implications for both fundamental research and clinical applications.
