Analytical Data
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基因名
CDK8
- Application
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别名
CDK8；Cyclin-dependent kinase 8
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P49336
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表达区间
1-464aa
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氨基酸序列
MDYDFKVKLS SERERVEDLF EYEGCKVGRG TYGHVYKAKR KDGKDDKDYA LKQIEGTGIS MSACREIALL RELKHPNVIS LQKVFLSHAD RKVWLLFDYA EHDLWHIIKF HRASKANKKP VQLPRGMVKS LLYQILDGIH YLHANWVLHR DLKPANILVM GEGPERGRVK IADMGFARLF NSPLKPLADL DPVVVTFWYR APELLLGARH YTKAIDIWAI GCIFAELLTS EPIFHCRQED IKTSNPYHHD QLDRIFNVMG FPADKDWEDI KKMPEHSTLM KDFRRNTYTN CSLIKYMEKH KVKPDSKAFH LLQKLLTMDP IKRITSEQAM QDPYFLEDPL PTSDVFAGCQ IPYPKREFLT EEEPDDKGDK KNQQQQQGNN HTNGTGHPGN QDSSHTQGPP LKKVRVVPPT TTSGGLIMTS DYQRSNPHAA YPNPGPSTSQ PQSSMGYSAT SQQPPQYSHQ THRY
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CDK8 (Cyclin-Dependent Kinase 8) is a key regulatory protein complex involved in the modulation of transcription and signaling pathways. As a member of the cyclin-dependent kinase family, CDK8 plays a crucial role in cell cycle regulation and transcriptional control by phosphorylating various target proteins. Its dysregulation has been implicated in numerous diseases, including cancer, where it can contribute to oncogene activation and tumor progression. Research has revealed that CDK8 acts as a co-activator in the transcriptional machinery, influencing the activity of several transcription factors. The understanding of its structure and function has paved the way for investigations into CDK8 as a potential therapeutic target. Recent studies have focused on characterizing CDK8 as a bipartite complex with several interacting partners, highlighting its significance in the differentiation of stem cells and response to environmental cues. Furthermore, the exploration of CDK8 inhibitors has gained momentum as a strategy for cancer treatment, as these small molecules can disrupt its activity and thus alter aberrant transcriptional programs associated with malignancy. Consequently, CDK8's role in orchestrating cellular processes makes it a focal point in biomedical research, prompting ongoing efforts to elucidate its mechanisms and therapeutic potential.
