Analytical Data
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基因名
UGT1A10
- Application
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别名
UGT1A10; GNT1; UGT1; UDP-glucuronosyltransferase 1A10; UGT1A10; UDP-glucuronosyltransferase 1-10; UDPGT 1-10; UGT1*10; UGT1-10; UGT1.10; UDP-glucuronosyltransferase 1-J; UGT-1J; UGT1J
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9HAW8
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表达区间
1-530 aa
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氨基酸序列
MARAGWTSPVPLCVCLLLTCGFAEAGKLLVVPMDGSHWFTMQSVVEKLILRGHEVVVVMPEVSWQLERSLNCTVKTYSTSYTLEDQNREFMVFAHAQWKARAQSIFSLLMSSSSGFLDLFFSHCRSLFNDRKLVEYLKESSFDAVFLDPFDTCGLIVAKYFSLPSVVFTRGIFCHHLEEGAQCPAPLSYVPNDLLGFSDAMTFKERVWNHIVHLEDHLFCQYLFRNALEIASEILQTPVTAYDLYSHTSIWLLRTDFVLDYPKPVMPNMIFIGGINCHQGKPLPMEFEAYINASGEHGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH
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分子量
84.04 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
UGT1A10 is a member of the UDP-glucuronosyltransferase (UGT) family, which plays a crucial role in the metabolism and detoxification of various endogenous and exogenous compounds through the process of glucuronidation. This enzyme catalyzes the conjugation of glucuronic acid to a variety of substrates, including drugs, hormones, and environmental pollutants, thereby enhancing their solubility and facilitating their excretion from the body. Research into UGT1A10 has gained attention due to its potential implications in pharmacogenetics, where genetic polymorphisms can influence an individual's metabolic capacity and drug response. Furthermore, alterations in UGT1A10 activity may be associated with various diseases, including cancer, highlighting its importance in biomedical research. The expression and functional characterization of recombinant UGT1A10 protein provide valuable insights into its enzymatic properties, substrate specificity, and regulatory mechanisms. Given the rising significance of personalized medicine, understanding the role of UGT1A10 in drug metabolism and its variations among individuals could pave the way for more targeted and effective therapeutic approaches. This research endeavors to elucidate the structure-activity relationship of UGT1A10, establish its pharmacokinetic profiles, and explore its interactions with different substrates, thereby advancing our knowledge of metabolic pathways and improving drug design and safety profiles.
