Analytical Data
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Gene name
UCHL5IP
- Application
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Alternative Names
26S proteasome-associated UCH interacting Protein 1; 26S proteasome-associated UCH37-interacting Protein 1; Expressed-Xq28STS Protein; HAUS augmin-like complex subunit 7; Haus7; HAUS7_HUMAN; HSXQ28ORF; UCH37 interacting Protein 1; UCHL5 interacting Protein; UCHL5-interacting Protein; UCHL5IP; UIP1; X-linked Protein STS1769
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q99871
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Expression Region
1-368 aa
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AA Sequence
MGGARLGARN MAGQDAGCGR GGDDYSEDEG DSSVSRAAVE VFGKLKDLNC PFLEGLYITE PKTIQELLCS PSEYRLEILE WMCTRVWPSL QDRFSSLKGV PTEVKIQEMT KLGHELMLCA PDDQELLKGC ACAQKQLHFM DQLLDTIRSL TIGCSSCSSL MEHFEDTREK NEALLGELFS SPHLQMLLNP ECDPWPLDMQ PLLNKQSDDW QWASASAKSE EEEKLAELAR QLQESAAKLH ALRTEYFAQH EQGAAAGAAD ISTLDQKLRL VTSDFHQLIL AFLQVYDDEL GECCQRPGPD LHPCGPIIQA THQNLTSYSQ LLQVVMAVAD TSAKAVETVK KQQGEQICWG GSSSVMSLAT KMNELMEK
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Molecular Weight
39.7 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
UCHL5 (Ubiquitin C-terminal hydrolase L5) is a member of the ubiquitin protease family, playing a crucial role in the regulation of ubiquitin-mediated protein degradation. It is primarily involved in the removal of ubiquitin from modified proteins, thus influencing various cellular processes such as cell cycle progression, DNA repair, and apoptosis. The study of UCHL5 is increasingly significant due to its potential implications in various diseases, including cancer and neurodegenerative disorders. Notably, aberrant expression levels of UCHL5 have been linked to tumor progression and poor prognosis in certain cancers, highlighting its role as a potential biomarker and therapeutic target. The generation of recombinant UCHL5 proteins allows for detailed biochemical characterization and investigation of its enzymatic activity, substrate specificity, and physiological functions. Researchers are particularly focused on elucidating the structural features of UCHL5 that confer its functional properties, as well as its interactions with other molecular partners in the ubiquitin-proteasome system. Understanding these mechanisms may provide insights into the development of novel therapeutic strategies aimed at modulating UCHL5 activity in disease contexts. Furthermore, the exploration of UCHL5 inhibitors or activators may offer new avenues for cancer treatment, as well as strategies for neuroprotection in neurodegenerative diseases. Overall, the study of recombinant UCHL5 proteins is critical for advancing our knowledge of ubiquitin signaling pathways and their implications in human health and disease.
