Analytical Data
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基因名
Rock2
- Application
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别名
Rock2；KIAA0619；Rho-associated Protein kinase 2
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O75116
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表达区间
5-554aa
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氨基酸序列
PPTGKMPGAPETAPGDGAGASRQRKLEALIRDPRSPINVESLLDGLNSLVLDLDFPALRKNKNIDNFLNRYEKIVKKIRGLQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVLKSQGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHKNSLCFPEDAEISKHAKNLICAFLTDREVRLGRNGVEEIRQHPFFKNDQWHWDNIRETAAPVVPELSSDIDSSNFDDIEDDKGDVETFPIPKAFVGNQLPFIGFTYYRENLLLSDSPSCRETDSIQSRKNEESQEIQKKLYTLEEHLSNEMQAKEELEQKCKSVNTRLEKTAKELEEEITLRKSVESALRQLEREKALLQHKNAEYQRKADHEADKKRNLENDVNSLKDQLEDLKKRNQNSQIST
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分子量
66 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Rock2 (Rho-associated protein kinase 2) is a serine/threonine kinase involved in various cellular processes, including cytoskeleton organization, cell migration, and apoptosis. Its regulation is crucial in both physiological and pathological contexts. Increased evidence suggests that Rock2 plays a pivotal role in cancer progression, cardiovascular diseases, and neurological disorders. By modulating the signaling pathways of Rho GTPases, Rock2 influences various cellular functions such as cell shape, adhesion, and motility, making it a significant target for therapeutic intervention. Recent studies have indicated that overexpression of Rock2 is associated with tumor cell invasion and metastasis, highlighting its potential as a biomarker for cancer prognosis. Moreover, Rock2's involvement in the stabilization of the actin cytoskeleton connects it to diseases characterized by altered cell morphology and motility. The exploration of Rock2 recombinant proteins facilitates the understanding of its structure-function relationship, enabling the development of specific inhibitors that could be beneficial in treating conditions like cancer and cardiovascular diseases. Additionally, the use of Rock2 as a research tool can elucidate the molecular mechanisms underlying its various roles in cellular signaling pathways. Understanding the functional implications of Rock2 at the molecular level is essential for the development of novel therapeutic strategies aimed at modulating its activity in disease contexts. Consequently, the continued investigation into the biochemical properties and biological significance of Rock2 is paramount for the advancement of targeted therapies and the improvement of patient outcomes in various diseases.
