Analytical Data
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Gene name
UBXD2
- Application
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Alternative Names
UBXN4; KIAA0242; UBXD2; UBXDC1; UBX domain-containing Protein 4; Erasin; UBX domain-containing Protein 2
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q92575
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Expression Region
1-508 aa
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AA Sequence
MLWFQGAIPA AIATAKRSGA VFVVFVAGDD EQSTQMAASW EDDKVTEASS NSFVAIKIDT KSEACLQFSQ IYPVVCVPSS FFIGDSGIPL EVIAGSVSAD ELVTRIHKVR QMHLLKSETS VANGSQSESS VSTPSASFEP NNTCENSQSR NAELCEIPPT SDTKSDTATG GESAGHATSS QEPSGCSDQR PAEDLNIRVE RLTKKLEERR EEKRKEEEQR EIKKEIERRK TGKEMLDYKR KQEEELTKRM LEERNREKAE DRAARERIKQ QIALDRAERA ARFAKTKEEV EAAKAAALLA KQAEMEVKRE SYARERSTVA RIQFRLPDGS SFTNQFPSDA PLEEARQFAA QTVGNTYGNF SLATMFPRRE FTKEDYKKKL LDLELAPSAS VVLLPAGRPT ASIVHSSSGD IWTLLGTVLY PFLAIWRLIS NFLFSNPPPT QTSVRVTSSE PPNPASSSKS EKREPVRKRV LEKRGDDFKK EGKIYRLRTQ DDGEDENNTW NGNSTQQM
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Molecular Weight
56.7 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
UBXD2, a member of the UBX protein family, has garnered significant interest in recent years due to its roles in various cellular processes, including protein degradation, apoptosis, and cellular signaling. It is known to interact with the proteasome and the ubiquitin-proteasome system, which are pivotal for maintaining cellular homeostasis by regulating protein turnover. Research has shown that UBXD2 acts as a co-factor that can modulate the activity of deubiquitinating enzymes and influence the stability of specific substrates. Additionally, its involvement in processes such as stress response and cellular metabolism highlights its potential implications in diseases, particularly cancer and neurodegenerative disorders. The ability of UBXD2 to regulate the balance between ubiquitination and deubiquitination makes it a critical player in cellular signaling pathways. Understanding the structure and function of UBXD2 through recombinant protein studies is essential for elucidating its mechanisms of action and potential therapeutic targets. By producing and characterizing UBXD2 in the laboratory, researchers aim to uncover its functional domains and interaction partners, which could pave the way for novel interventions in diseases associated with dysregulated protein homeostasis. Overall, the study of UBXD2 as a recombinant protein represents an important step toward comprehensively understanding its biological significance and therapeutic potential.
