Analytical Data
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基因名
UBP1
- Application
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别名
UBP1; LBP1; Upstream-binding Protein 1; Transcription factor LBP-1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9NZI7
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表达区间
1-540 aa
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氨基酸序列
MAWVLKMDEV IESGLVHDFD ASLSGIGQEL GAGAYSMSDV LALPIFKQED SSLPLDGETE HPPFQYVMCA ATSPAVKLHD ETLTYLNQGQ SYEIRMLDNR KMGDMPEING KLVKSIIRVV FHDRRLQYTE HQQLEGWKWN RPGDRLLDLD IPMSVGIIDT RTNPSQLNAV EFLWDPAKRT SAFIQVHCIS TEFTPRKHGG EKGVPFRIQV DTFKQNENGE YTDHLHSASC QIKVFKPKGA DRKQKTDREK MEKRTAHEKE KYQPSYDTTI LTEMRLEPII EDAVEHEQKK SSKRTLPADY GDSLAKRGSC SPWPDAPTAY VNNSPSPAPT FTSPQQSTCS VPDSNSSSPN HQGDGASQTS GEQIQPSATI QETQQWLLKN RFSSYTRLFS NFSGADLLKL TKEDLVQICG AADGIRLYNS LKSRSVRPRL TIYVCREQPS STVLQGQQQA ASSASENGSG APYVYHAIYL EEMIASEVAR KLALVFNIPL HQINQVYRQG PTGIHILVSD QMVQNFQDES CFLFSTVKAE SSDGIHIILK
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分子量
60.4 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
UBP1 (Ubiquitin C-Terminal Hydrolase L1) is a member of the deubiquitinating enzyme (DUB) family, which plays a critical role in regulating protein stability and cellular signaling pathways by cleaving ubiquitin chains from substrate proteins. This regulation is essential for diverse cellular processes, including the cell cycle, DNA repair, and responses to stress. UBP1, in particular, has garnered attention due to its involvement in various diseases, including cancer and neurodegeneration, where aberrant ubiquitination patterns can lead to cellular dysfunction. Research into UBP1 recombinant proteins aims to elucidate its enzymatic activity, substrate specificity, and functional roles within the ubiquitin-proteasome system. By producing and characterizing UBP1 in vitro, scientists can better understand how its deubiquitinating activity influences cellular homeostasis and pathology. This knowledge could pave the way for developing therapeutic strategies targeting UBP1 for treating diseases associated with dysregulation of ubiquitin signaling. Furthermore, the exploration of UBP1's interactions with other proteins and pathways could reveal novel insights into its role in disease mechanisms, making it a significant focus of ongoing biochemical and biomedical research.
