Analytical Data
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基因名
Txn1
- Application
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别名
Txn; Txn1; Thioredoxin; Trx; ATL-derived factor; ADF
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种属
Mouse
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P10639
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表达区间
2-105 aa
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氨基酸序列
VKLIESKEA FQEALAAAGD KLVVVDFSAT WCGPCKMIKP FFHSLCDKYS NVVFLEVDVD DCQDVAADCE VKCMPTFQFY KKGQKVGEFS GANKEKLEAS ITEYA
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分子量
11.6 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Txn1, or Thioredoxin 1, is a small redox-active protein that plays a pivotal role in cellular antioxidant defense and protein folding. It is part of the thioredoxin family and is ubiquitously expressed in various tissues, highlighting its fundamental role in maintaining redox homeostasis. The research on Txn1 has gained momentum due to its involvement in various physiological processes, including cellular proliferation, apoptosis, and response to oxidative stress. Dysregulation of Txn1 has been linked to several pathologies, such as cancer, neurodegenerative diseases, and cardiovascular disorders, making it a target of interest for therapeutic interventions. To explore its biological functions and potential clinical applications, recombinant expression and purification of Txn1 have become crucial. Advances in recombinant DNA technology enable researchers to produce high quantities of functional Txn1, facilitating in-depth studies of its structure-function relationships, interactive partners, and mechanisms of action. This research not only aims to elucidate the biochemical pathways involving Txn1 but also seeks to harness its properties for drug development and therapeutic strategies against diseases characterized by oxidative stress and protein misfolding.
