Analytical Data
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基因名
TWISTNB
- Application
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别名
DNA directed RNA polymerase I subunit RPA43; DNA-directed RNA polymerase I subunit RPA43; RPA43; RPA43_HUMAN; TWIST neighbor; Twist neighbor Protein; Twistnb
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q3B726
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表达区间
1-338 aa
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氨基酸序列
MAAGCSEAPR PAAASDGSLV GQAGVLPCLE LPTYAAACAL VNSRYSCLVA GPHQRHIALS PRYLNRKRTG IREQLDAELL RYSESLLGVP IAYDNIKVVG ELGDIYDDQG HIHLNIEADF VIFCPEPGQK LMGIVNKVSS SHIGCLVHGC FNASIPKPEQ LSAEQWQTME INMGDELEFE VFRLDSDAAG VFCIRGKLNI TSLQFKRSEV SEEVTENGTE EAAKKPKKKK KKKDPETYEV DSGTTKLADD ADDTPMEESA LQNTNNANGI WEEEPKKKKK KKKHQEVQDQ DPVFQGSDSS GYQSDHKKKK KKRKHSEEAE FTPPLKCSPK RKGKSNFL
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分子量
37.4 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TWISTNB is a recombinant protein that has garnered significant attention in the field of biochemistry and molecular biology due to its unique structural and functional properties. Derived from the TWIST family of helix-loop-helix transcription factors, TWISTNB plays a crucial role in various biological processes, including cell differentiation, proliferation, and apoptosis. The study of TWISTNB is particularly relevant in cancer research, as it has been implicated in the regulation of epithelial-mesenchymal transition (EMT), a process that allows cancer cells to acquire migratory and invasive capabilities. Through reprogramming cellular pathways, TWISTNB can influence tumor progression and metastasis, making it a potential target for therapeutic intervention. Additionally, the expression and activity of TWISTNB are often altered in various cancers, thus serving as a biomarker for disease prognosis. Advances in recombinant DNA technology have enabled the production of TWISTNB in vitro, facilitating detailed investigations into its mechanisms of action and interactions with other cellular components. This foundational research not only enhances our understanding of cancer biology but also paves the way for the development of novel therapeutic strategies aimed at inhibiting TWISTNB-related pathways, thereby holding promise for improved cancer treatment outcomes. The ongoing exploration of TWISTNB's properties and functions continues to reveal its pivotal role in modern biomedical research, underscoring the importance of recombinant protein studies in addressing complex health challenges.
