Analytical Data
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Gene name
FBXW9
- Application
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Alternative Names
F box and WD 40 domain containing protein 9; F box/WD repeat containing protein 9 ; F-box and WD-40 domain-containing protein 9; F-box/WD repeat-containing protein 9; FBW9; FBXW9; FBXW9_HUMAN; Specificity factor for SCF ubiquitin ligase
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q5XUX1
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Expression Region
1-488aa
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AA Sequence
MELPLGRCDD SRTWDDDSDP ESETDPDAQA KAYVARVLSP PKSGLAFSRP SQLSTPAASP SASEPRAASR VSAVSEPGLL SLPPELLLEI CSYLDARLVL HVLSRVCHAL RDLVSDHVTW RLRALRRVRA PYPVVEEKNF DWPAACIALE QHLSRWAEDG RWVEYFCLAE GHVASVDSVL LLQGGSLCLS GSRDRNVNLW DLRQLGTESN QVLIKTLGTK RNSTHEGWVW SLAAQDHRVC SGSWDSTVKL WDMAADGQQF GEIKASSAVL CLSYLPDILV TGTYDKKVTI YDPRDRMETR DALMGWGGPS RGSDIPPHRP ITHEAGPALL KHQQLHSRPV LTLLADDRHI ISGSEDHTLV VVDRRANSVL QRLQLDSYLL CMSYQEPQLW AGDNQGLLHV FANRNGCFQL IRSFDVGHSF PITGIQYSVG ALYTTSTDKT IRVHVPTDPP RTICTRRHDN GLNRVCAEGN LVVAGSGDLS LEVWRLQA
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Molecular Weight
50.7 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
FBXW9, a member of the F-box protein family, plays a critical role in the ubiquitin-proteasome pathway, which is essential for protein degradation and turnover in eukaryotic cells. The research background surrounding FBXW9 has gained momentum due to its involvement in regulating various cellular processes, including cell cycle progression, apoptosis, and signaling pathways. Abnormalities in FBXW9 expression and function have been linked to several diseases, particularly cancer, where it may influence tumor growth and progression by modulating the stability of key oncogenic and tumor suppressor proteins. Furthermore, FBXW9 has been suggested to interact with specific substrates involved in immune responses, indicating its potential role in immune regulation. Recent studies have focused on elucidating the precise molecular mechanisms by which FBXW9 exerts its functions, including its substrate specificity and the impact of post-translational modifications on its activity. Understanding FBXW9's role in cellular homeostasis and disease pathogenesis can provide insights into novel therapeutic targets and strategies for intervention in diseases characterized by dysregulated protein turnover. As such, ongoing research aims to explore the potential of FBXW9 as a biomarker for disease progression and as a target for therapeutic development, highlighting the importance of this F-box protein in cellular regulation and disease.
