Analytical Data
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Gene name
FBXW5
- Application
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Alternative Names
FBXW5; FBW5; PP3971F-box/WD repeat-containing protein 5; F-box and WD-40 domain-containing protein 5
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q969U6
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Expression Region
1-566aa
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AA Sequence
MDEGGTPLLP DSLVYQIFLS LGPADVLAAG LVCRQWQAVS RDEFLWREQF YRYYQVARDV PRHPAAMSWY EEFQRLYDTV PCVEVQTLRE HTDQVLHLSF SHSGYQFASC SKDCTVKIWS NDLTISLLHS ADMRPYNWSY TQFSQFNKDD SLLLASGVFL GPHNSSSGEI AVISLDSFAL LSRVRNKPYD VFGCWLTETS LISGNLHRIG DITSCSVLWL NNAFQDVESE NVNVVKRLFK IQNLNASTVR TVMVADCSRF DSPDLLLEAG DPATSPCRIF DLGSDNEEVV AGPAPAHAKE GLRHFLDRVL EGRAQPQLSE RMLETKVAEL LAQGHTKPPE RSATGAKSKY LIFTTGCLTY SPHQIGIKQI LPHQMTTAGP VLGEGRGSDA FFDALDHVID IHGHIIGMGL SPDNRYLYVN SRAWPNGAVV ADPMQPPPIA EEIDLLVFDL KTMREVRRAL RAHRAYTPND ECFFIFLDVS RDFVASGAED RHGYIWDRHY NICLARLRHE DVVNSVVFSP QEQELLLTAS DDATIKAWRS PRTMRVLQAP RPRPRTFFSW LASQRR
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Molecular Weight
63.9 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
FBXW5, a member of the F-box protein family, plays a crucial role in the ubiquitin-proteasome pathway, which is essential for protein degradation and cellular regulation. Research on FBXW5 has gained momentum due to its involvement in various cellular processes, including cell cycle regulation, apoptosis, and signal transduction. Initially identified as a regulator of the phosphorylation state of specific target proteins, FBXW5 has since been implicated in several pathophysiological conditions, such as cancer and neurodegenerative diseases. Studies have shown that FBXW5 can modulate the stability of key oncoproteins and tumor suppressors, suggesting its significant role in tumorigenesis. Furthermore, FBXW5's interactions with various cellular partners highlight its potential as a therapeutic target, as disrupting these interactions may influence disease progression and treatment response. Understanding the precise mechanisms by which FBXW5 contributes to cellular function and pathology could provide valuable insights into new therapeutic strategies, making it a focal point of contemporary biomedical research.
