Analytical Data
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基因名
FBXO45
- Application
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别名
F box protein 45; F-box only protein 45; F-box/SPRY domain-containing protein 1; FBSP1_HUMAN; FBX45; fbxo45; hFbxo45
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P0C2W1
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表达区间
2-286aa
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氨基酸序列
AAPAPGAGA ASGGAGCSGG GAGAGAGSGS GAAGAGGRLP SRVLELVFSY LELSELRSCA LVCKHWYRCL HGDENSEVWR SLCARSLAEE ALRTDILCNL PSYKAKIRAF QHAFSTNDCS RNVYIKKNGF TLHRNPIAQS TDGARTKIGF SEGRHAWEVW WEGPLGTVAV IGIATKRAPM QCQGYVALLG SDDQSWGWNL VDNNLLHNGE VNGSFPQCNN APKYQIGERI RVILDMEDKT LAFERGYEFL GVAFRGLPKV CLYPAVSAVY GNTEVTLVYL GKPLDG
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分子量
30.6 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
FBXO45 (F-box protein 45) is a member of the F-box protein family, which is known for its role in ubiquitin-proteasome mediated protein degradation. As a substrate recognition component of SCF (SKP1-Cullin-F-box) ubiquitin ligase complexes, FBXO45 plays a critical role in regulating various cellular processes, including cell cycle progression, signal transduction, and differentiation. Recent studies have highlighted its involvement in regulating the stability of key proteins, such as cyclins and transcription factors, impacting important pathways associated with cancer and other diseases. Given the significance of FBXO45 in cellular homeostasis and disease pathology, researchers have focused on characterizing its structure, substrate specificity, and regulatory mechanisms. The recombinant expression of FBXO45 facilitates the study of its functional properties and interactions in a controlled laboratory setting, enabling detailed investigations into its role in ubiquitination and signaling pathways. Understanding the biochemical and molecular dynamics of FBXO45 can provide insights into its potential as a therapeutic target and the broader implications of F-box proteins in cellular regulation.
