Analytical Data
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基因名
ALT2
- Application
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别名
ALT2；AAT2；ALT2；Alanine aminotransferase 2
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8TD30
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表达区间
1-523aa
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氨基酸序列
MGSSHHHHHH SSGLVPRGSH MGSMQRAAAL VRRGCGPRTP SSWGRSQSSA AAEASAVLKV RPERSRRERI LTLESMNPQV KAVEYAVRGP IVLKAGEIEL ELQRGIKKPF TEVIRANIGD AQAMGQQPIT FLRQVMALCT YPNLLDSPSF PEDAKKRARR ILQACGGNSL GSYSASQGVN CIREDVAAYI TRRDGGVPAD PDNIYLTTGA SDGISTILKI LVSGGGKSRT GVMIPIPQYP LYSAVISELD AIQVNYYLDE ENCWALNVNE LRRAVQEAKD HCDPKVLCII NPGNPTGQVQ SRKCIEDVIH FAWEEKLFLL ADEVYQDNVY SPDCRFHSFK KVLYEMGPEY SSNVELASFH STSKGYMGEC GYRGGYMEVI NLHPEIKGQL VKLLSVRLCP PVSGQAAMDI VVNPPVAGEE SFEQFSREKE SVLGNLAKKA KLTEDLFNQV PGIHCNPLQG AMYAFPRIFI PAKAVEAAQA HQMAPDMFYC MKLLEETGIC VVPGSGFGQR EGTYHFRMTI LPPVEKLKTV LQKVKDFHIN FLEKYA
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分子量
60 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The ALT2 protein is a member of the ALT (Alternative Lengthening of Telomeres) pathway, which is a crucial mechanism for telomere maintenance in certain types of cancer cells, particularly those that are not reliant on the telomerase enzyme. Research into ALT mechanisms has gained significant attention due to their implications in tumor biology and potential therapeutic targets, as these pathways allow cancer cells to proliferate indefinitely despite the cytotoxic effects of telomere shortening. The ALT2 variant, in particular, has been less studied compared to other ALT-related proteins; however, preliminary investigations suggest it might play a pivotal role in telomere dynamics and stability in ALT-positive tumors. Understanding the structure and function of ALT2 proteins could shed light on the molecular underpinnings of telomere maintenance strategies utilized by cancer cells. Furthermore, the study of ALT2 may provide insights into novel biomarkers for cancer prognosis or progression, as well as potential targets for developing therapies that specifically disrupt these ALT pathways, ultimately enhancing the effectiveness of cancer treatments. The research surrounding ALT2 recombinant proteins is thus a rapidly expanding field that holds promise for contributing to our understanding of cancer biology and improving treatment strategies for malignancies that utilize telomere maintenance through the ALT mechanism.
