Analytical Data
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Gene name
FBXO38
- Application
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Alternative Names
FBXO38; SP329F-box only protein 38
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q6PIJ6
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Expression Region
1-426aa
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AA Sequence
MEEGDAESSVCPRCCCHRPQESQRRTSRCSDEERPSTSRACVVNGPDGTRSAFSFRTLPQGGSSGPAHDERTNGSGSGATGEDRRGSSQPESCDVQSNEDYPRRPLTRARSRLSHVLLVSESEVAKTKPRHAMKRKRTADKSTSTSDPVIEDDHVQVLVLKSKNLVGVTMTNCGITDLVLKDCPKMMFIHATRCRVLKHLKVENAPIVNRFDYAQCKKLNMDQVLDQILRMPPERNRIIYLRPMQQVDTLTLEQKLFSGPYPYHICIIHEFSNPPNVRNKVRIRSWMDTIANINQELIKYEFFPEATRSEEDLKKYPKYPWGREIYTLEGVVDGAPYSMISDFPWLRSLRAAEPNSFARYDFEDDEESTIYAPRRKGQLSADICMETIGEEISEMRQMKKGVFQRVVAIFIHYCDVNGEPVEDDYI
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Molecular Weight
75.1 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
FBXO38 is a member of the F-box protein family, which plays a crucial role in the ubiquitin-proteasome system by mediating the degradation of target proteins. This family of proteins is involved in various cellular processes, including cell cycle regulation, signal transduction, and transcriptional control. Recent studies have indicated that FBXO38 is associated with several pathological conditions, including cancer, neurodegenerative diseases, and immune disorders. Its ability to recognize and ubiquitinate specific substrates suggests that FBXO38 may serve as a potential therapeutic target for modulating these diseases. Moreover, understanding the precise mechanisms through which FBXO38 regulates protein degradation can provide insights into its functional roles in cellular homeostasis and disease progression. Researchers are increasingly focused on characterizing FBXO38 and its interaction network to elucidate its biological significance and potential implications in therapeutic strategies. The development of recombinant FBXO38 proteins is thus a vital step towards examining its structure-function relationship, facilitating the identification of its substrates, and exploring its therapeutic potential in various biomedical applications. The exploration of FBXO38's role in the context of different diseases may pave the way for innovative approaches in drug discovery and the development of targeted therapies, highlighting the critical need for further research in this area.
