Analytical Data
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基因名
FBXO38
- Application
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别名
FBXO38; SP329F-box only protein 38
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q6PIJ6
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表达区间
1-426aa
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氨基酸序列
MEEGDAESSVCPRCCCHRPQESQRRTSRCSDEERPSTSRACVVNGPDGTRSAFSFRTLPQGGSSGPAHDERTNGSGSGATGEDRRGSSQPESCDVQSNEDYPRRPLTRARSRLSHVLLVSESEVAKTKPRHAMKRKRTADKSTSTSDPVIEDDHVQVLVLKSKNLVGVTMTNCGITDLVLKDCPKMMFIHATRCRVLKHLKVENAPIVNRFDYAQCKKLNMDQVLDQILRMPPERNRIIYLRPMQQVDTLTLEQKLFSGPYPYHICIIHEFSNPPNVRNKVRIRSWMDTIANINQELIKYEFFPEATRSEEDLKKYPKYPWGREIYTLEGVVDGAPYSMISDFPWLRSLRAAEPNSFARYDFEDDEESTIYAPRRKGQLSADICMETIGEEISEMRQMKKGVFQRVVAIFIHYCDVNGEPVEDDYI
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分子量
75.1 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
FBXO38 is a member of the F-box protein family, which plays a crucial role in the ubiquitin-proteasome system by mediating the degradation of target proteins. This family of proteins is involved in various cellular processes, including cell cycle regulation, signal transduction, and transcriptional control. Recent studies have indicated that FBXO38 is associated with several pathological conditions, including cancer, neurodegenerative diseases, and immune disorders. Its ability to recognize and ubiquitinate specific substrates suggests that FBXO38 may serve as a potential therapeutic target for modulating these diseases. Moreover, understanding the precise mechanisms through which FBXO38 regulates protein degradation can provide insights into its functional roles in cellular homeostasis and disease progression. Researchers are increasingly focused on characterizing FBXO38 and its interaction network to elucidate its biological significance and potential implications in therapeutic strategies. The development of recombinant FBXO38 proteins is thus a vital step towards examining its structure-function relationship, facilitating the identification of its substrates, and exploring its therapeutic potential in various biomedical applications. The exploration of FBXO38's role in the context of different diseases may pave the way for innovative approaches in drug discovery and the development of targeted therapies, highlighting the critical need for further research in this area.
