Analytical Data
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基因名
FBXO39
- Application
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别名
FBXO39; FBX39F-box only protein 39
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8N4B4
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表达区间
1-442aa
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氨基酸序列
MDEESELIQPQDQSCWAFLPDLCLCRVFWWLGDRDRSRAALVCRKWNQMMYSAELWRYRTITFSGRPSRVHASEVESAVWYVKKFGRYLEHLEVKFMNPYNAVLTKKFQVTMRGLLSCLSKSNNRLKSLSIQYLELDRLVWRNSIRSSFISSLSFFLKKMGKRLDYLNLKGARLTVEQGCQILDSLSYMRNENVISELNIEDYFSHHLAVYNSPQFKKTMSTFHNLVSLNLNYNCISDELLENLCENASTLRTINIKCHVHDPHGQVIWGMSWAKLARQATNLKVNFFFERIMKYERLARILLQEIPIRSISLRSCYFSDPDCSMRPTLIDLLPTFRHTLQKLTCEFNNNHESLDEELHLLIISCRKLFYFKIWAFLDVSFVERILKSQKERQCALRVFKARIYTNRYETNEEDKTLQEIYRKYRKLIESELSYFVIVYSVM
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分子量
74.14 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
FBXO39, a member of the F-box protein family, plays a pivotal role in the ubiquitin-proteasome system, which is crucial for regulating protein degradation and turnover in eukaryotic cells. The study of FBXO39 has gained importance due to its involvement in various biological processes, including cell cycle regulation, signal transduction, and the modulation of protein interactions. Dysregulation of FBXO39 expression has been implicated in several diseases, including cancer, where it may influence tumor progression and metastasis by affecting the stability of key regulatory proteins. Research has focused on the identification of substrates for FBXO39, elucidating its interacting partners, and understanding its mechanistic roles in cellular pathways. Advances in recombinant protein technologies have enabled the production of FBXO39 for in vitro studies, facilitating the exploration of its function and interactions at a molecular level. Furthermore, characterizing FBXO39’s structure and function may provide insights into its potential as a therapeutic target, as manipulating its activity could offer novel strategies for disease intervention. Thus, the investigation of FBXO39 and its recombinant protein form represents a promising frontier in understanding cellular dynamics and developing innovative therapeutic approaches.
