Analytical Data
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Gene name
TUBB2B
- Application
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Alternative Names
TUBB2BTubulin beta-2B chain
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9BVA1
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Expression Region
1-445 aa
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AA Sequence
MREIVHIQAG QCGNQIGAKF WEVISDEHGI DPTGSYHGDS DLQLERINVY YNEATGNKYV PRAILVDLEP GTMDSVRSGP FGQIFRPDNF VFGQSGAGNN WAKGHYTEGA ELVDSVLDVV RKESESCDCL QGFQLTHSLG GGTGSGMGTL LISKIREEYP DRIMNTFSVM PSPKVSDTVV EPYNATLSVH QLVENTDETY CIDNEALYDI CFRTLKLTTP TYGDLNHLVS ATMSGVTTCL RFPGQLNADL RKLAVNMVPF PRLHFFMPGF APLTSRGSQQ YRALTVPELT QQMFDSKNMM AACDPRHGRY LTVAAIFRGR MSMKEVDEQM LNVQNKNSSY FVEWIPNNVK TAVCDIPPRG LKMSATFIGN STAIQELFKR ISEQFTAMFR RKAFLHWYTG EGMDEMEFTE AESNMNDLVS EYQQYQDATA DEQGEFEEEE GEDEA
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Molecular Weight
49.9 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TUBB2B, a member of the tubulin family, plays a crucial role in neuronal development and function. It is primarily expressed in the central nervous system and is essential for the formation of microtubules, which are vital for maintaining cellular structure and intracellular transport. Mutations in the TUBB2B gene have been associated with various neurological disorders, including cortical malformations and other developmental brain anomalies. Research into TUBB2B recombinant proteins has gained significant attention as scientists aim to understand its precise functions and the mechanisms underlying these mutations' effects. By producing and analyzing TUBB2B proteins in a controlled laboratory environment, researchers can investigate their biochemical properties, stability, and interactions with other cellular components. This knowledge is essential for developing potential therapeutic strategies for disorders linked to TUBB2B mutations. Furthermore, studying TUBB2B recombinantly can shed light on the broader implications of tubulin dynamics in neurodevelopmental processes, paving the way for advancements in regenerative medicine and targeted therapies. Overall, TUBB2B recombinant protein research not only enhances our understanding of tubulin-related functions in neurons but also holds promise for uncovering novel approaches to treat related neurological conditions.
