Analytical Data
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Gene name
TTRAP
- Application
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Alternative Names
5'-Tyr-DNA phosphodiesterase; 5'-tyrosyl-DNA phosphodiesterase; AD 022; AD022; dJ30M3.3; EAP 2; EAP II; EAP2; EAPII; ETS 1 associated Protein 2; ETS 1 associated Protein II; ETS1 associated Protein 2; ETS1 associated Protein II; ETS1-associated Protein 2; ETS1-associated Protein II; MGC111021; MGC9099; RP1-30M3.3; tdp2; TRAF and TNF receptor associated Protein; TRAF and TNF receptor-associated Protein; TTRAP; TYDP2_HUMAN; Tyr DNA phosphodiesterase 2; Tyr-DNA phosphodiesterase 2; Tyrosyl DNA phosphodiesterase 2; Tyrosyl-DNA phosphodiesterase 2
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O95551
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Expression Region
1-362 aa
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AA Sequence
MELGSCLEGG REAAEEEGEP EVKKRRLLCV EFASVASCDA AVAQCFLAEN DWEMERALNS YFEPPVEESA LERRPETISE PKTYVDLTNE ETTDSTTSKI SPSEDTQQEN GSMFSLITWN IDGLDLNNLS ERARGVCSYL ALYSPDVIFL QEVIPPYYSY LKKRSSNYEI ITGHEEGYFT AIMLKKSRVK LKSQEIIPFP STKMMRNLLC VHVNVSGNEL CLMTSHLEST RGHAAERMNQ LKMVLKKMQE APESATVIFA GDTNLRDREV TRCGGLPNNI VDVWEFLGKP KHCQYTWDTQ MNSNLGITAA CKLRFDRIFF RAAAEEGHII PRSLDLLGLE KLDCGRFPSD HWGLLCNLDI IL
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Molecular Weight
40.9 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TTRAP (TRAF and TNF receptor-associated protein) is a crucial protein involved in various cellular processes, including signal transduction, immune responses, and apoptosis. Research on TTRAP has intensified due to its role in modulating the activity of tumor necrosis factor (TNF) receptors and its implications in inflammatory diseases and cancer. As an adaptor protein, TTRAP interacts with a range of signaling molecules, influencing pathways such as NF-kB and MAPK, which are pivotal in cell survival and inflammatory responses. The potential involvement of TTRAP in regulating apoptosis offers insights into its function in tumorigenesis, making it a target of interest for therapeutic interventions. Recent studies have focused on the recombinant expression of TTRAP to elucidate its structural properties and functional mechanisms. These recombinant proteins are essential for performing biochemical assays and understanding TTRAP's interactions with other proteins, thus paving the way for novel drug development and targeting strategies in diseases linked to dysregulated TNF signaling. By generating TTRAP as a recombinant protein, researchers aim to gain deeper insights into its role in cellular dynamics and therapeutic potential, enhancing our understanding of diseases where TTRAP plays a critical role.
