Analytical Data
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基因名
TTLL9
- Application
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别名
C20orf125; Probable tubulin polyglutamylase TTLL9; Ttll9; TTLL9_HUMAN; Tubulin--tyrosine ligase-like Protein 9
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q3SXZ7
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表达区间
1-439 aa
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氨基酸序列
MVPSREALLG PGTTAIRCPK KLQNQNYKGH GLSKGKEREQ RASIRFKTTL MNTLMDVLRH RPGWVEVKDE GEWDFYWCDV SWLRENFDHT YMDEHVRISH FRNHYELTRK NYMVKNLKRF RKQLEREAGK LEAAKCDFFP KTFEMPCEYH LFVEEFRKNP GITWIMKPVA RSQGKGIFLF RRLKDIVDWR KDTRSSDDQK DDIPVENYVA QRYIENPYLI GGRKFDLRVY VLVMSVFAEC LLWSGHRRQD VHLTNVAVQK TSPDYHPKKG CKWTLQRFRQ YLASKHGPEA VETLFRDIDN IFVKSLQSVQ KVIISDKHCF ELYGYDILID QDLKPWLLEV NASPSLTASS QEDYELKTCL LEDTLHVVDM EARLTGREKR VGGFDLMWND GPVSREEGAP DLSGMGNFVT NTHLGCVNDR KKQLRQLFCS LQVQKKASS
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分子量
51.4 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TTLL9 (tubulin tyrosine ligase-like 9) is a member of the TTLL family of enzymes known for their role in the post-translational modification of tubulin, a key protein in cellular structure and function. Research has indicated that TTLL9 specifically catalyzes the addition of tyrosine to the C-terminal of tubulin, which is crucial for microtubule stability and cellular signaling pathways. Dysregulation of tubulin modifications has been implicated in various diseases, including cancer and neurodegenerative disorders, making TTLL9 an important focus for understanding cellular dynamics. Additionally, TTLL9 is believed to participate in the regulation of neuronal function and development, linking it to studies in neurobiology. The production of recombinant TTLL9 protein has opened avenues for in vitro studies, allowing researchers to dissect its enzymatic activity, interaction with tubulin, and potential involvement in cellular processes. Understanding TTLL9’s function could lead to insights into therapeutic strategies aimed at modulating tubulin-related pathways in disease contexts.
