Analytical Data
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基因名
CASP12
- Application
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别名
CASP12；Inactive caspase-12
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q6UXS9
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表达区间
1-341aa
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氨基酸序列
MADEKPSNGV LVHMVKLLIK TFLDGIFDDL MENNVLNTDE IHLIGKCLKF VVSNAENLVD DITETAQTAG KIFREHLWNS KKQLSSDISS DGEREANMPG LNIRNKEFNY LHNRNGSELD LLGMRDLLEN LGYSVVIKEN LTAQEMETAL RQFAAHPEHQ SSDSTFLVFM SHSILNGICG TKHWDQEPDV LHDDTIFEIF NNRNCQSLKD KPKVIIMQAC RGNGAGIVWF TTDSGKAGAD THGRLLQGNI CNDAVTKAHV EKDFIAFKSS TPHNVSWRHE TNGSVFISQI IYYFREYSWS HHLEEIFQKV QHSFETPNIL TQLPTIERLS MTRYFYLFPG N
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CASP12 (Caspase-12) is an important member of the caspase family, which plays a crucial role in apoptosis and inflammation. It is primarily localized in the endoplasmic reticulum and is involved in the cellular response to stress, particularly in the context of innate immunity and the inflammatory response. Research has shown that CASP12 is implicated in the processing of pro-inflammatory cytokines and can influence the development of various diseases, including sepsis and neurodegenerative disorders. Interestingly, genetic variations in the CASP12 gene have been associated with different susceptibilities to infectious diseases, suggesting its role in the human immune response. Additionally, its expression levels can vary among populations, indicating a potential evolutionary adaptation. The investigation of recombinant CASP12 protein has gained traction as it allows for a better understanding of its functional roles, mechanisms of action, and interactions with other cellular components. By employing modern molecular biology techniques, researchers aim to elucidate the biochemistry of CASP12, which may lead to novel therapeutic strategies targeting inflammatory processes and apoptosis-related diseases. This research is vital for leveraging CASP12 as a biomarker for certain conditions or as a target for drug development, thereby contributing to advancements in medical science and treatment modalities.
