Analytical Data
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基因名
TTF2
- Application
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别名
F2; Factor 2; Factor2; HuF 2; HuF2; Human factor 2; Lodestar homolog; Lodestar Protein; RNA polymerase II termination factor; Transcription release factor 2; Transcription termination factor 2; Transcription termination factor RNA polymerase II; TTF2; TTF2_HUMAN
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9UNY4
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表达区间
1-373 aa
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氨基酸序列
MTAESGPPPPQPEVLATVKEERGETAAGAGVPGEATGRGAGGRRRKRPLQRGKPPYSYIALIAMAIAHAPERRLTLGGIYKFITERFPFYRDNPKKWQNSIRHNLTLNDCFLKIPREAGRPGKGNYWALDPNAEDMFESGSFLRRRKRFKRSDLSTYPAYMHDAAAAAAAAAAAAAAAAIFPGAVPAARPPYPGAVYAGYAPPSLAAPPPVYYPAASPGPCRVFGLVPERPLSPELGPAPSGPGGSCAFASAGAPATTTGYQPAGCTGARPANPSAYAAAYAGPDGAYPQGAGSAIFAAAGRLAGPASPPAGGSSGGVETTVDFYGRTSPGQFGALGACYNPGGQLGGASAGAYHARHAAAYPGGIDRFVSAM
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分子量
67.43 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TTF2 (Transcription Termination Factor 2) is a crucial protein involved in the regulation of gene expression by facilitating the termination of transcription processes in eukaryotic cells. Its role extends beyond the mere termination of transcription; TTF2 contributes to the accuracy of RNA polymerase II in completing the transcription cycle, thereby preventing premature termination and ensuring the synthesis of full-length messenger RNA (mRNA). The study of TTF2 recombinant proteins has garnered increasing interest due to its potential implications in understanding various cellular mechanisms, including gene regulation, cellular response to stress, and the maintenance of genome integrity. Additionally, TTF2 has been implicated in certain pathologies, such as cancer, where dysregulation of transcriptional processes can lead to uncontrolled cell growth. By exploring the structure and function of TTF2 through recombinant protein technology, researchers aim to elucidate its biochemical properties, interactions with other molecules, and the pathways influenced by its activity. This research not only enhances our fundamental understanding of transcriptional regulation but also opens avenues for therapeutic interventions targeting transcriptional dysregulation in diseases. The ability to produce TTF2 in a recombinant system enables detailed biochemical assays, structural studies, and the development of potential inhibitors, making it a significant focus in molecular biology and biochemistry.
