Analytical Data
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基因名
CASP5
- Application
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别名
CASP5；ICH3；Caspase-5
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P51878
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表达区间
137-327aa
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氨基酸序列
DQKITSVKPLLQIEAGPPESAESTNILKLCPREEFLRLCKKNHDEIYPIKKREDRRRLALIICNTKFDHLPARNGAHYDIVGMKRLLQGLGYTVVDEKNLTARDMESVLRAFAARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGEKHGELWVRD
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分子量
23.8kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CASP5, or Caspase-5, is a member of the caspase family of cysteine proteases, which play crucial roles in the execution of apoptosis and the inflammatory response. It is particularly important in the context of immune regulation and has been implicated in various diseases, including autoimmune disorders and cancers. The study of CASP5 recombinant protein is essential for understanding its functional mechanisms as well as its potential as a therapeutic target. By producing CASP5 in a recombinant form, researchers can investigate its enzymatic activity, substrate specificity, and interactions with other cellular proteins. This research also paves the way for developing inhibitors that could modulate its activity in disease states. Given the complex roles that caspases play in apoptosis and inflammation, exploring the properties and functions of CASP5 through recombinant protein studies will contribute to a deeper understanding of how dysregulation of this pathway could lead to pathologies, thus facilitating the identification of novel intervention strategies. Overall, the investigation of CASP5 recombinant protein not only enhances our fundamental knowledge of cellular processes but also holds promise for advancing therapeutic approaches in diseases characterized by aberrant apoptosis and inflammation.
