Analytical Data
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Gene name
ZNF57
- Application
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Alternative Names
ZNF57; ZNF424; Zinc finger Protein 57; Zinc finger Protein 424
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q68EA5
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Expression Region
1-609 aa
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AA Sequence
MPHLLVTFRDVAIDFSQEEWECLDPAQRDLYRDVMLENYSNLISLDLESSCVTKKLSPEKEIYEMESLQWENMGKRINHHLQYNGLGDNMECKGNLEGQEANQEGLYMCVKITCEEKATESHSTSSTFHRIIPTKEKLYKCKECRQGFSYLSCLIQHEENHNIEKCSEVKKHRNTFSKKPSYIQHQRIHTGEKPYECMECGKAFGRTSDLIQHQKIHTNEKPYQCNACGKAFIRGSQLTEHQRVHTGEKPYECKKCGKAFSYCSQYTLHQRIHSGEKPYECKDCGKAFILGSQLTYHQRIHSGEKPYECKECGKAFILGSHLTYHQRVHTGEKPYICKECGKAFLCASQLNEHQRIHTGEKPYECKECGKTFFRGSQLTYHLRVHSGERPYKCKECGKAFISNSNLIQHQRIHTGEKPYKCKECGKAFICGKQLSEHQRIHTGEKPFECKECGKAFIRVAYLTQHEKIHGEKHYECKECGKTFVRATQLTYHQRIHTGEKPYKCKECDKAFIYGSQLSEHQRIHRGEKPYECKQCGKAFIRGSHLTEHLRTHTGEKPYECKECGRAFSRGSELTLHQRIHTGEKPYTCVQCGKDFRCPSQLTQHTRLHN
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Molecular Weight
97.2 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ZNF57 (Zinc Finger Protein 57) is a member of the Krüppel-like family of transcription factors, primarily known for its crucial role in genomic imprinting and epigenetic regulation. Its ability to bind to specific DNA sequences and recruit co-factors to modify chromatin structure makes ZNF57 a significant protein in the regulation of gene expression. Research on ZNF57 has gained traction due to its involvement in various developmental processes and its implications in diseases, such as cancers and genetic disorders. Understanding the functional mechanisms of ZNF57 is pivotal for elucidating the roles of epigenetic marks in gene regulation. Recombinant ZNF57 proteins have been produced to study its structure, binding affinities, and downstream effects on target genes. By employing techniques such as crystallography and NMR spectroscopy, researchers aim to gain insights into the protein's conformational states and the molecular interactions that dictate its regulatory functions. Furthermore, the investigation of ZNF57’s interactions with other proteins and nucleic acids can unveil pathways that are fundamental in maintaining cellular homeostasis and identity. As such, ZNF57 remains a focal point for ongoing research, with potential therapeutic applications aimed at modulating its activity to treat diseases associated with aberrant gene expression and epigenetic dysregulation. The comprehensive study of recombinant ZNF57 will not only enhance our understanding of gene regulation but also drive innovations in epigenetic therapy and personalized medicine.
