Analytical Data
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基因名
ZNF57
- Application
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别名
ZNF57; ZNF424; Zinc finger Protein 57; Zinc finger Protein 424
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q68EA5
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表达区间
1-609 aa
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氨基酸序列
MPHLLVTFRDVAIDFSQEEWECLDPAQRDLYRDVMLENYSNLISLDLESSCVTKKLSPEKEIYEMESLQWENMGKRINHHLQYNGLGDNMECKGNLEGQEANQEGLYMCVKITCEEKATESHSTSSTFHRIIPTKEKLYKCKECRQGFSYLSCLIQHEENHNIEKCSEVKKHRNTFSKKPSYIQHQRIHTGEKPYECMECGKAFGRTSDLIQHQKIHTNEKPYQCNACGKAFIRGSQLTEHQRVHTGEKPYECKKCGKAFSYCSQYTLHQRIHSGEKPYECKDCGKAFILGSQLTYHQRIHSGEKPYECKECGKAFILGSHLTYHQRVHTGEKPYICKECGKAFLCASQLNEHQRIHTGEKPYECKECGKTFFRGSQLTYHLRVHSGERPYKCKECGKAFISNSNLIQHQRIHTGEKPYKCKECGKAFICGKQLSEHQRIHTGEKPFECKECGKAFIRVAYLTQHEKIHGEKHYECKECGKTFVRATQLTYHQRIHTGEKPYKCKECDKAFIYGSQLSEHQRIHRGEKPYECKQCGKAFIRGSHLTEHLRTHTGEKPYECKECGRAFSRGSELTLHQRIHTGEKPYTCVQCGKDFRCPSQLTQHTRLHN
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分子量
97.2 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ZNF57 (Zinc Finger Protein 57) is a member of the Krüppel-like family of transcription factors, primarily known for its crucial role in genomic imprinting and epigenetic regulation. Its ability to bind to specific DNA sequences and recruit co-factors to modify chromatin structure makes ZNF57 a significant protein in the regulation of gene expression. Research on ZNF57 has gained traction due to its involvement in various developmental processes and its implications in diseases, such as cancers and genetic disorders. Understanding the functional mechanisms of ZNF57 is pivotal for elucidating the roles of epigenetic marks in gene regulation. Recombinant ZNF57 proteins have been produced to study its structure, binding affinities, and downstream effects on target genes. By employing techniques such as crystallography and NMR spectroscopy, researchers aim to gain insights into the protein's conformational states and the molecular interactions that dictate its regulatory functions. Furthermore, the investigation of ZNF57’s interactions with other proteins and nucleic acids can unveil pathways that are fundamental in maintaining cellular homeostasis and identity. As such, ZNF57 remains a focal point for ongoing research, with potential therapeutic applications aimed at modulating its activity to treat diseases associated with aberrant gene expression and epigenetic dysregulation. The comprehensive study of recombinant ZNF57 will not only enhance our understanding of gene regulation but also drive innovations in epigenetic therapy and personalized medicine.
