Analytical Data
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Gene name
MRC1
- Application
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Alternative Names
MRC1；CLEC13D；CLEC13DL；MRC1L1；Macrophage mannose receptor 1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P22897
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Expression Region
655-1213aa
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AA Sequence
RTSLCFKLYAKGKHEKKTWFESRDFCRALGGDLASINNKEEQQTIWRLITASGSYHKLFWLGLTYGSPSEGFTWSDGSPVSYENWAYGEPNNYQNVEYCGELKGDPTMSWNDINCEHLNNWICQIQKGQTPKPEPTPAPQDNPPVTEDGWVIYKDYQYYFSKEKETMDNARAFCKRNFGDLVSIQSESEKKFLWKYVNRNDAQSAYFIGLLISLDKKFAWMDGSKVDYVSWATGEPNFANEDENCVTMYSNSGFWNDINCGYPNAFICQRHNSSINATTVMPTMPSVPSGCKEGWNFYSNKCFKIFGFMEEERKNWQEARKACIGFGGNLVSIQNEKEQAFLTYHMKDSTFSAWTGLNDVNSEHTFLWTDGRGVHYTNWGKGYPGGRRSSLSYEDADCVVIIGGASNEAGKWMDDTCDSKRGYICQTRSDPSLTNPPATIQTDGFVKYGKSSYSLMRQKFQWHEAETYCKLHNSLIASILDPYSNAFAWLQMETSNERVWIALNSNLTDNQYTWTDKWRVRYTNWAADEPKLKSACVYLDLDGYWKTAHCNESFYFLCK
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Molecular Weight
69.9 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MRC1 (Macrophage Receptor with a C-lectin domain 1) is a receptor predominantly expressed in macrophages that plays a critical role in mediating immune responses and tissue homeostasis. It is known for its ability to recognize and bind glycoproteins and polysaccharides, thereby facilitating the phagocytosis of pathogens and apoptotic cells. Research on recombinant MRC1 protein has gained momentum in recent years due to its potential applications in immunotherapy and vaccine development. Understanding the structure and function of MRC1 can help elucidate its role in modulating immune responses, particularly in the context of infectious diseases and cancer. The recombinant production of MRC1 allows for detailed studies on its ligand interactions, signaling pathways, and its influence on macrophage polarization. Furthermore, characterizing MRC1's binding properties can provide insights into how it can be utilized as a target for drug delivery systems or as a biomarker for various diseases. As the field of immunology continues to advance, the exploration of MRC1 recombinant protein not only enhances our knowledge of macrophage biology but also holds promise for developing novel therapeutic strategies aimed at manipulating immune responses for better health outcomes.
