Analytical Data
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Gene name
ZNF498
- Application
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Alternative Names
ZSCAN25; ZNF498Zinc finger and SCAN domain-containing Protein 25; Zinc finger Protein 498
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q6NSZ9
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Expression Region
1-544 aa
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AA Sequence
MLKEHPEMAEAPQQQLGIPVVKLEKELPWGRGREDPSPETFRLRFRQFRYQEAAGPQEALRELQELCRRWLRPELHTKEQILELLVLEQFLTILPREFYAWIREHGPESGKALAAMVEDLTERALEAKAVPCHRQGEQEETALCRGAWEPGIQLGPVEVKPEWGMPPGEGVQGPDPGTEEQLSQDPGDETRAFQEQALPVLQAGPGLPAVNPRDQEMAAGFFTAGSQGLGPFKDMALAFPEEEWRHVTPAQIDCFGEYVEPQDCRVSPGGGSKEKEAKPPQEDLKGALVALTSERFGEASLQGPGLGRVCEQEPGGPAGSAPGLPPPQHGAIPLPDEVKTHSSFWKPFQCPECGKGFSRSSNLVRHQRTHEEKSYGCVECGKGFTLREYLMKHQRTHLGKRPYVCSECWKTFSQRHHLEVHQRSHTGEKPYKCGDCWKSFSRRQHLQVHRRTHTGEKPYTCECGKSFSRNANLAVHRRAHTGEKPYGCQVCGKRFSKGERLVRHQRIHTGEKPYHCPACGRSFNQRSILNRHQKTQHRQEPLVQ
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Molecular Weight
87.9 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
ZNF498, a member of the zinc finger protein family, has garnered significant interest in recent years due to its potential roles in various biological processes, including gene regulation, cellular differentiation, and tumorigenesis. Research indicates that ZNF498 functions as a transcriptional regulator, influencing the expression of key genes involved in cell cycle and apoptosis. Its unique structure, characterized by multiple zinc finger domains, facilitates interactions with DNA and other proteins, making it a crucial component in transcriptional complexes. Recent studies have revealed that aberrations in the expression levels or functions of ZNF498 are linked to several cancers, suggesting its involvement in oncogenic pathways. Furthermore, ZNF498 has been implicated in maintaining genomic stability, highlighting its potential importance in disease mechanisms. Recombinant ZNF498 protein is invaluable for advancing our understanding of its functional roles, enabling detailed investigations into its molecular interactions and effects on cellular processes. By characterizing the biochemical properties and biological activities of this protein, researchers aim to elucidate its contributions to health and disease, ultimately laying the groundwork for potential therapeutic applications targeting ZNF498-related pathways. As such, the study of recombinant ZNF498 protein not only enhances our comprehension of complex regulatory networks but also holds promise for novel strategies in cancer treatment and other disorders associated with its dysregulation.
