Analytical Data
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基因名
TRPC3
- Application
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别名
TRPC3; TRP3; Short transient receptor potential channel 3; TrpC3; Transient receptor Protein 3; TRP-3; hTrp-3; hTrp3
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q13507
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表达区间
1-214 aa
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氨基酸序列
MYVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMTTGAWIFTGGVNTGVIRHVGDALKDHASKSRGKICTIGIAPWGIVENQEDLIGRDVVRPYQTMSNPMSKLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINTSFHSYKTAHVDLQDKRQVKTALEQAEWQPGRGLFDHDNLMQST
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分子量
50.5 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TRPC3, or Transient Receptor Potential Cation Channel Subfamily C Member 3, is an important member of the TRP ion channel family, which plays a crucial role in various physiological processes, including calcium influx, cellular signaling, and sensory perception. Research on TRPC3 has gained momentum due to its involvement in several pathophysiological conditions, such as cardiac hypertrophy, neurodegeneration, and inflammatory diseases. The TRPC3 protein is activated by various stimuli, including receptor interactions and membrane depolarization, which allows it to mediate intracellular calcium levels and contribute to the modulation of neuronal excitability and muscle contraction. Given its significant role in cellular functions, the recombination and expression of TRPC3 are vital for investigating its structure-function relationships and its regulatory mechanisms. Researchers have utilized recombinant protein techniques to produce TRPC3 in heterologous systems, facilitating biochemical characterization, functional assays, and high-throughput screening for potential pharmacological modulators. Understanding the precise mechanisms of TRPC3 activation and regulation can unveil therapeutic targets for diseases where TRPC3 is implicated. Consequently, generating a recombinant TRPC3 protein is essential not only for advancing basic scientific knowledge but also for exploring its potential as a drug target in the treatment of various channelopathies and related disorders. As the body of research grows, the elucidation of TRPC3's role in health and disease will likely lead to new strategies for intervention in disorders linked to dysfunctional calcium signaling.
