Analytical Data
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Gene name
LRH1
- Application
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Alternative Names
LRH1；BAF60C；SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O00482
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Expression Region
1-541aa
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AA Sequence
MSSNSDTGDL QESLKHGLTP IGAGLPDRHG SPIPARGRLV MLPKVETEAL GLARSHGEQG QMPENMQVSQ FKMVNYSYDE DLEELCPVCG DKVSGYHYGL LTCESCKGFF KRTVQNNKRY TCIENQNCQI DKTQRKRCPY CRFQKCLSVG MKLEAVRADR MRGGRNKFGP MYKRDRALKQ QKKALIRANG LKLEAMSQVI QAMPSDLTIS SAIQNIHSAS KGLPLNHAAL PPTDYDRSPF VTSPISMTMP PHGSLQGYQT YGHFPSRAIK SEYPDPYTSS PESIMGYSYM DSYQTSSPAS IPHLILELLK CEPDEPQVQA KIMAYLQQEQ ANRSKHEKLS TFGLMCKMAD QTLFSIVEWA RSSIFFRELK VDDQMKLLQN CWSELLILDH IYRQVVHGKE GSIFLVTGQQ VDYSIIASQA GATLNNLMSH AQELVAKLRS LQFDQREFVC LKFLVLFSLD VKNLENFQLV EGVQEQVNAA LLDYTMCNYP QQTEKFGQLL LRLPEIRAIS MQAEEYLYYK HLNGDVPYNN LLIEMLHAKR A
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The LRH-1 (Liver Receptor Homolog-1) protein, a member of the nuclear receptor superfamily, plays a crucial role in various physiological processes, including glucose metabolism, cholesterol homeostasis, and reproductive functions. Its importance is highlighted by its involvement in regulating gene expression related to lipid metabolism, insulin sensitivity, and steroidogenesis. Studies have shown that dysfunctional LRH-1 signaling can contribute to metabolic disorders, such as obesity and type 2 diabetes, making it a potential therapeutic target. Moreover, LRH-1 is implicated in cancer biology, particularly in breast and prostate cancers, where it may function as an oncogene. The complexity of LRH-1's regulation and its interactions with other nuclear receptors and coregulators underscore the need for in-depth studies. To advance our understanding of LRH-1's functional mechanisms, researchers are focusing on the development of recombinant LRH-1 proteins. These recombinantly produced proteins facilitate the investigation of LRH-1’s biochemical properties, interaction partners, and downstream signaling pathways in controlled experimental settings. Such research endeavors aim to elucidate LRH-1's role in health and disease, paving the way for novel therapeutic strategies targeting this critical nuclear receptor. As a result, the characterization and study of LRH-1 recombinant proteins are essential for unlocking its biological significance and potential clinical applications.
