Cat: PA1000-8432

Recombinant Human HCRP1 Protein,His

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Analytical Data

  • Gene name

    HCRP1

  • Application

    SPRMSTBLIITCELISACELL ASSAYDRUG SCREENING

  • Alternative Names

    HCRP1;HCRP1;Vacuolar Protein sorting-associated Protein 37A

  • Species

    Human

  • Source

    E. coli

  • Tag

    His tag N-Terminus

  • Purity

    Greater than 90% as determined by SDS-PAGE.

  • Uniprot

    Q8NEZ2

  • Expression Region

    1-397aa

  • AA Sequence

    MSWLFPLTKS ASSSAAGSPG GLTSLQQQKQ RLIESLRNSH SSIAEIQKDV EYRLPFTINN LTININILLP PQFPQEKPVI SVYPPIRHHL MDKQGVYVTS PLVNNFTMHS DLGKIIQSLL DEFWKNPPVL APTSTAFPYL YSNPSGMSPY ASQGFPFLPP YPPQEANRSI TSLSVADTVS SSTTSHTTAK PAAPSFGVLS NLPLPIPTVD ASIPTSQNGF GYKMPDVPDA FPELSELSVS QLTDMNEQEE VLLEQFLTLP QLKQIITDKD DLVKSIEELA RKNLLLEPSL EAKRQTVLDK YELLTQMKST FEKKMQRQHE LSESCSASAL QARLKVAAHE AEEESDNIAE DFLEGKMEID DFLSSFMEKR TICHCRRAKE EKLQQAIAMH SQFHAPL

  • Endotoxin

    < 1.0 EU per μg protein as determined by the LAL method.

  • Form

    Freeze-dried powder

  • Buffer formulation

    PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.

  • Reconstitution

    Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.

  • Customization

    Site-directed mutagenesis Custom tag design Custom buffer formulation Custom full-length protein production

  • Stability Test

    The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.

  • Storage & Shelf Life

    Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

  • Shipping

    In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.

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Protein Description

HCRP1, or the Human Cardiac Repressor Protein 1, is a crucial transcriptional regulator primarily expressed in cardiac tissues. Its role has garnered substantial interest in recent years due to its implications in cardiac development and disease. Research shows that HCRP1 is involved in the modulation of various signaling pathways, which influence cardiomyocyte differentiation and cardiac hypertrophy. Dysregulation of HCRP1 expression has been linked to several cardiovascular diseases, including heart failure and arrhythmias, highlighting its potential as a therapeutic target. The recombinant protein form of HCRP1 is particularly valuable for studying its functional mechanisms, as well as for exploring its role in cellular processes and interactions with other proteins. Advances in recombinant DNA technology have facilitated the production of HCRP1, enabling in vitro functional assays and structural studies, which are essential for understanding its molecular properties and developing innovative treatments for heart-related ailments. As cardiovascular diseases remain a leading cause of morbidity and mortality worldwide, ongoing research into the HCRP1 recombinant protein promises to illuminate new pathways for intervention and may significantly contribute to improving cardiac health outcomes.

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