Analytical Data
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Gene name
TRAF3IP1
- Application
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Alternative Names
Interleukin 13 receptor alpha 1 binding Protein 1; Interleukin-13 receptor alpha 1-binding Protein 1; Microtubule interacting Protein that associates with TRAF3; Microtubule-interacting Protein associated with TRAF3; MIP T3; MIP-T3; MIPT3; MIPT3_HUMAN; TNF receptor associated factor 3 interacting Protein 1; TRAF3-interacting Protein 1; Traf3ip1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8TDR0
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Expression Region
1-691 aa
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AA Sequence
MNAAVVRRTQ EALGKVIRRP PLTEKLLSKP PFRYLHDIIT EVIRMTGFMK GLYTDAEMKS DNVKDKDAKI SFLQKAIDVV VMVSGEPLLA KPARIVAGHE PERTNELLQI IGKCCLNKLS SDDAVRRVLA GEKGEVKGRA SLTSRSQELD NKNVREEESR VHKNTEDRGD AEIKERSTSR DRKQKEELKE DRKPREKDKD KEKAKENGGN RHREGERERA KARARPDNER QKDRGNRERD RDSERKKETE RKSEGGKEKE RLRDRDRERD RDKGKDRDRR RVKNGEHSWD LDREKNREHD KPEKKSASSG EMSKKLSDGT FKDSKAETET EISTRASKSL TTKTSKRRSK NSVEGRKEDN ISAKSLDSIV SGINNEPNQE TTTSEIGTKE ANINSTSISD DNSASLRCEN IQPNPTEKQK GDSTSDAEGD AGPAGQDKSE VPETPEIPNE LSSNIRRIPR PGSARPAPPR VKRQDSMEAL QMDRSGSGKT VSNVITESHN SDNEEDDQFV VEAAPQLSEM SEIEMVTAVE LEEEEKHGGL VKKILETKKD YEKLQQSPKP GEKERSLFES AWKKEKDIVS KEIEKLRTSI QTLCKSALPL GKIMDYIQED VDAMQNELQM WHSENRQHAE ALQQEQRITD CAVEPLKAEL AELEQLIKDQ QDKICAVKAN ILKNEEKIQK MVYSINLTSR R
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Molecular Weight
78.6 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
TRAF3IP1, also known as Act1, is a pivotal adaptor protein involved in various cellular signaling pathways, particularly those linked to immune responses. As a member of the tumor necrosis factor receptor-associated factor (TRAF) family, TRAF3IP1 plays a critical role in mediating downstream signaling from receptors such as IL-17 and TNF. Research has shown that TRAF3IP1 is essential for pro-inflammatory cytokine production and the regulation of T helper 17 (Th17) cell responses, contributing to autoimmune and inflammatory diseases. Dysregulation of TRAF3IP1 is associated with conditions such as rheumatoid arthritis, multiple sclerosis, and psoriasis. The study of TRAF3IP1 recombinant proteins offers insight into its structural and functional properties, allowing for the exploration of its role in modulating immune responses. Understanding the molecular interactions and mechanisms by which TRAF3IP1 influences signaling pathways can reveal potential therapeutic targets for treating autoimmune disorders. Through the development and characterization of TRAF3IP1 recombinant proteins, researchers aim to elucidate its function in pathology and uncover innovative strategies for intervention in diseases driven by aberrant immune signaling. Thus, TRAF3IP1 represents a significant focus for both basic research and clinical applications, with the potential to advance knowledge in immunology and the treatment of related disorders.
