Analytical Data
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Gene name
ATP2A2
- Application
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Alternative Names
ATP2A2；ATPIIA；KIAA0611；Probable phospholipid-transporting ATPase IIA
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P16615
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Expression Region
314-756aa
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AA Sequence
VITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFILDRVEGDTCSLNEFTITGSTYAPIGEVHKDDKPVNCHQYDGLVELATICALCNDSALDYNEAKGVYEKVGEATETALTCLVEKMNVFDTELKGLSKIERANACNSVIKQLMKKEFTLEFSRDRKSMSVYCTPNKPSRTSMSKMFVKGAPEGVIDRCTHIRVGSTKVPMTSGVKQKIMSVIREWGSGSDTLRCLALATHDNPLRREEMHLEDSANFIKYETNLTFVGCVGMLDPPRIEVASSVKLCRQAGIRVIMITGDNKGTAVAICRRIGIFGQDEDVTSKAFTGREFDELNPSAQRDACLNARCFARVEPSHKSKIVEFLQSFDEITAMTGDGVNDAPALKKAEIGIAMGSGTAVAKTASEMVLADDNFSTIVAAVEEGRAIYNNM
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Molecular Weight
55.2 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ATP2A2, also known as Sarcoplasmic Reticulum Ca²⁺-ATPase (SERCA2), plays a crucial role in calcium homeostasis within cells, particularly in muscle tissues. This protein is responsible for the active transport of calcium ions from the cytoplasm into the sarcoplasmic reticulum, a function essential for muscle relaxation and proper cardiac function. Dysregulation of ATP2A2 has been implicated in various cardiac and skeletal muscle diseases, including dilated cardiomyopathy and myopathies associated with mutations in the ATP2A2 gene. Research into recombinant ATP2A2 proteins aims to enhance our understanding of its structure-function relationships and regulatory mechanisms. By expressing ATP2A2 in various heterologous systems, scientists can investigate how mutations impact its activity and stability, paving the way for the development of targeted therapies. Additionally, characterizing ATP2A2 through recombinant techniques provides insights into its interactions with other cellular proteins and its role in signaling pathways related to calcium dysfunction. Overall, ATP2A2 research is vital for uncovering potential therapeutic targets and enhancing our understanding of calcium-related pathologies.
