Analytical Data
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Gene name
TOMM40L
- Application
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Alternative Names
TOMM40L; TOMM40B; Mitochondrial import receptor subunit TOM40B; Protein TOMM40-like
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q969M1
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Expression Region
1-308 aa
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AA Sequence
MGNTLGLAPM GTLPRRSPRR EEPLPNPGSF DELHRLCKDV FPAQMEGVKL VVNKVLSSHF QVAHTIHMSA LGLPGYHLHA AYAGDWQLSP TEVFPTVVGD MDSSGSLNAQ VLLLLAERLR AKAVFQTQQA KFLTWQFDGE YRGDDYTATL TLGNPDLIGE SVIMVAHFLQ SLTHRLVLGG ELVYHRRPGE EGAILTLAGK YSAVHWVATL NVGSGGAHAS YYHRANEQVQ VGVEFEANTR LQDTTFSFGY HLTLPQANMV FRGLVDSNWC VGAVLEKKMP PLPVTLALGA FLNHWRNRFH CGFSITVG
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Molecular Weight
33.9 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
TOMM40L, a member of the translocase of the outer mitochondrial membrane (TOM) complex, plays a crucial role in mitochondrial protein import and is essential for mitochondrial function. Recent research has indicated that variations in the TOMM40 gene may be associated with the risk of developing neurodegenerative diseases, particularly Alzheimer's disease. The gene's polymorphisms have been linked to the regulation of mitochondrial dynamics and bioenergetics, highlighting its importance in cellular health and pathology. Given the increasing prevalence of age-related diseases, understanding the functional implications of TOMM40L and its protein product could provide insights into mitochondrial-related mechanisms of disease. Furthermore, exploring TOMM40L's role in mitochondrial biogenesis and apoptosis offers potential therapeutic avenues for protecting neuronal health. This has spurred interest in the development of recombinant TOMM40L proteins for functional studies and the exploration of their interactions with other mitochondrial proteins. Such research could ultimately contribute to novel strategies for the prevention and treatment of conditions associated with mitochondrial dysfunction.
