Analytical Data
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基因名
PARP4
- Application
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别名
PARP4；ADPRTL1；KIAA0177；PARPL；Protein mono-ADP-ribosyltransferase PARP4
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9UKK3
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表达区间
607-1046aa
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氨基酸序列
SSTKAGLQDASGNLVPLEDVHIKGRIIDTVAQVIVFQTYTNKSHVPIEAKYIFPLDDKAAVCGFEAFINGKHIVGEIKEKEEAQQEYLEAVTQGHGAYLMSQDAPDVFTVSVGNLPPKAKVLIKITYITELSILGTVGVFFMPATVAPWQQDKALNENLQDTVEKICIKEIGTKQSFSLTMSIEMPYVIEFIFSDTHELKQKRTDCKAVISTMEGSSLDSSGFSLHIGLSAAYLPRMWVEKHPEKESEACMLVFQPDLDVDLPDLASESEVIICLDCSSSMEGVTFLQAKQIALHALSLVGEKQKVNIIQFGTGYKELFSYPKHITSNTMAAEFIMSATPTMGNTDFWKTLRYLSLLYPARGSRNILLVSDGHLQDESLTLQLVKRSRPHTRLFACGIGSTANRHVLRILSQCGAGVFEYFNAKSKHSWRKQIEDQMTRL
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分子量
55.0 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PARP4 (Poly(ADP-ribose) polymerase 4) is a member of the PARP protein family, known for its role in cellular processes such as DNA repair, apoptosis, and gene regulation. Unlike its better-studied relatives, PARP1 and PARP2, which are primarily associated with the repair of DNA damage, PARP4 has emerged as a protein of interest due to its unique structural features and diverse functions. Recent research indicates that PARP4 plays a critical role in the regulation of cell survival, proliferation, and development, particularly in response to environmental stressors. It is speculated that PARP4 may be involved in modulating the cell's response to DNA damage and maintaining genomic stability, thus influencing tumorigenesis. Furthermore, studies have suggested that PARP4 interacts with various proteins, including transcription factors and chromatin remodelers, implicating it in the regulation of gene expression. These insights have prompted researchers to investigate the potential of PARP4 as a therapeutic target in cancer treatment, especially in tumors characterized by dysregulated DNA repair mechanisms. As a result, understanding the functional roles and mechanisms of PARP4 through recombinant protein studies is crucial for elucidating its biological implications and therapeutic potentials.
