Analytical Data
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基因名
EXOSC9
- Application
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别名
EXOSC9. PMSCL1
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q06265
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表达区间
124-220aa
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氨基酸序列
DPNEREERVMDGLLVIAMNKHREICTIQSSGGIMLLKDQVLRCSKIAGVKVAEITELILKALENDQKVRKEGGKFGFAESIANQRITAFKMEKAPID
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分子量
36.41 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
EXOSC9, part of the exonuclease complex involved in RNA processing, has garnered increasing attention due to its pivotal role in cellular RNA metabolism and gene regulation. This protein is a key component of the RNA exosome complex, which is responsible for the degradation of various RNA species, including defective or unneeded transcripts, thus ensuring proper gene expression and maintaining RNA homeostasis. Mutations in EXOSC9 are associated with various genetic disorders, particularly those affecting neurological development, highlighting its importance in human health. Understanding the structure and function of EXOSC9 is critical for unraveling the mechanisms underlying these diseases. The study of recombinant EXOSC9 proteins allows researchers to investigate their enzymatic activity, interactions with other RNA processing factors, and their roles in the exosome complex's function. Recent advancements in protein expression systems and purification techniques have facilitated these investigations, paving the way for potential therapeutic strategies targeting EXOSC9-related pathologies. Additionally, recombinant EXOSC9 can be utilized in biochemical assays to explore its substrate specificity and regulation, contributing valuable insights into RNA metabolism and its broader implications in cellular function and disease. Overall, the exploration of EXOSC9 through recombinant protein studies not only enhances our understanding of fundamental biological processes but also opens avenues for addressing RNA-related diseases.












