Analytical Data
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Gene name
EXOD1
- Application
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Alternative Names
ERI2; EXOD1; KIAA1504; ERI1 exoribonuclease 2; EC 3.1.-.-; Exonuclease domain-containing protein 1
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
A8K979
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Expression Region
1-328aa
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AA Sequence
MATKRLARQLGLIRRKSIAPANGNLGRSKSKQLFDYLIVIDFESTCWNDGKHHHSQEIIEFPAVLLNTSTGQIDSEFQAYVQPQEHPILSEFCMELTGIKQAQVDEGVPLKICLSQFCKWIHKIQQQKNIIFATGISEPSASEVKLCAFVTWSDWDLGVCLEYECKRKQLLKPVFLNSWIDLRATYKLFYRRKPKGLSGALQEVGIEFSGREHSGLDDSRNTALLAWKMIRDGCVMKITRSLNKGPFLLPSWTWNSDLASGDQHAFLKQEFGCGTYRTLLQKPNMSKQEKGNILWLTMVWLSLACLQRKNYNDCMLNTASQTVTTEKF
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Molecular Weight
63.9 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
EXOD1, also known as Exosome Component 1, is a key protein involved in RNA metabolism, particularly in the exosomal pathway, which plays a crucial role in cellular communication and the regulation of various biological processes. The interest in EXOD1 has surged due to its potential implications in cancer biology, neurodegenerative diseases, and viral infections. Research has shown that EXOD1 is involved in the degradation of specific RNA molecules, thereby influencing gene expression and cellular responses to stress. Additionally, its role in exosome biogenesis and secretion positions it as a vital player in the modulation of the extracellular environment and intercellular interactions. Understanding the structure and function of EXOD1 through recombinant protein studies can provide insights into its mechanisms of action and how it contributes to disease pathology. This research is essential for developing targeted therapeutic strategies that can manipulate exosomal pathways for disease treatment or prevention. Furthermore, the study of EXOD1's biochemical properties and interactions with other cellular components can enhance our knowledge of RNA metabolism, potentially revealing novel regulatory networks within the cell. As such, EXOD1 serves as a significant model for investigating the complexities of RNA processing and its regulation in health and disease settings.
