Analytical Data
-
Gene name
TMPRSS3
- Application
-
Alternative Names
TMPRSS3; ECHOS1; TADG12; UNQ323/PRO382; Transmembrane protease serine 3; Serine protease TADG-12; Tumor-associated differentially-expressed gene 12 Protein
-
Species
Human
-
Source
E. coli
-
Tag
GST-tag at N-terminal
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
P57727
-
Expression Region
1-437 aa
-
AA Sequence
MLQDPDSDQPLNSLDVKPLRKPRIPMETFRKVGIPIIIALLSLASIIIVVVLIKVILDKYYFLCGQPLHFIPRKQLCDGELDCPLGEDEEHCVKSFPEGPAVAVRLSKDRSTLQVLDSATGNWFSACFDNFTEALAETACRQMGYSSKPTFRAVEIGPDQDLDVVEITENSQELRMRNSSGPCLSGSLVSLHCLACGKSLKTPRVVGGEEASVDSWPWQVSIQYDKQHVCGGSILDPHWVLTAAHCFRKHTDVFNWKVRAGSDKLGSFPSLAVAKIIIIEFNPMYPKDNDIALMKLQFPLTFSGTVRPICLPFFDEELTPATPLWIIGWGFTKQNGGKMSDILLQASVQVIDSTRCNADDAYQGEVTEKMMCAGIPEGGVDTCQGDSGGPLMYQSDQWHVVGIVSWGYGCGGPSTPGVYTKVSAYLNWIYNVWKAEL
-
Molecular Weight
73.7 kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
TMPRSS3 (Transmembrane Protease, Serine 3) is a serine protease that has garnered significant attention in the fields of molecular biology and medicine due to its role in various physiological and pathological processes. Originally identified as a gene associated with hearing loss, recent studies have unveiled its involvement in the activation of several key proteins, including certain viral glycoproteins necessary for viral entry into host cells. This has positioned TMPRSS3 as a potential target for therapeutic interventions, particularly in the context of viral infections such as influenza and coronaviruses. Furthermore, its broader implications in cancer biology, where it may influence tumor progression and metastasis, highlight the necessity for a deeper understanding of its biological functions and regulatory mechanisms. Recombining TMPRSS3 protein provides a unique opportunity to explore its activity, interactions, and potential inhibitory strategies, paving the way for novel therapeutic approaches. The ongoing research aims to elucidate its specific roles, optimize its recombinant production for various applications, and assess its potential as a biomarker or therapeutic target. Overall, elucidating the multifaceted roles of TMPRSS3 through recombinant protein studies could lead to significant advancements in both infectious disease treatment and cancer therapy.
